TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis

Table 2

Constant parameters for diagnostic calculations.

Symbol	Explanation	Value	Reference
𝛽	Correction coefficient for log-linear model	−0.1345	[120]
𝛼𝑇	Dilution factor for T4 (reciprocal of apparent volume of distribution)	0,1 L^−1	[11, 23]
𝛽𝑇	Clearance exponent for T4	1,1 * 10^−6 sec^−1	[11, 23, 292]
𝐷𝑇	EC50 for TSH	2,75 mU/L	[11, 23, 293]
𝐾41	Dissociation constant T4-TBG	2 * 10^10 L/mol	[11, 23, 106]
𝐾42	Dissociation constant T4-TBPA	2 * 10^8 L/mol	[11, 23, 106]
𝛼31	Dilution factor for T3	0,026 L^−1	[11, 23]
𝛽31	Clearance exponent for T3	8 * 10^−6 sec^−1	[11, 23]
𝐾𝑀1	Dissociation constant of type 1 deiodinase	5 * 10^−7 mol/L	[11, 23, 294]
𝐾30	Dissociation constant T3-TBG	2 * 10^9 L/mol	[11, 23, 295]