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Journal of Thyroid Research
Volume 2012, Article ID 469397, 5 pages
Clinical Study

Factors Influencing the Outcome of Patients with Incidental Papillary Thyroid Microcarcinoma

1Endocrine, Diabetes, Nutrition and Metabolism Department, University Hospital of Vigo, P.O. Box 1691, Plaza de Compostela 3, 36201 Vigo, Spain
2Research Unit, University Hospital of Vigo, 36204 Vigo, Spain

Received 9 July 2012; Revised 5 September 2012; Accepted 5 September 2012

Academic Editor: P. Beck-Peccoz

Copyright © 2012 Beatriz Mantinan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To analyze some factors that could influence the outcome of patients with PTMC. Material and Methods. This is a longitudinal observational study. All patients diagnosed and treated for papillary thyroid microcarcinoma at the University Hospital of Vigo, between January 1994 and December 2003, were included in the present study. Demographic characteristics, tumour characteristics, TNM stage, rate of recurrence, and treatment with 131I were the study variables. Results. Ninety-one patients (75 females) with an average age of years, range 19–81, were studied. Initial tumour staging was T1 in 90 patients and T4a in 1 case. Initial lymph node involvement was present in 4 cases (4.4%). We only found one case with distant metastases at diagnosis. Postsurgical evaluation of thyroid specimens revealed that 28 (30.7%) tumours were multifocal. The average size of the tumour was  cm, range 0.1–1. Univariate analysis reveals a statistically significant association between tumour multifocality and postsurgical 131I therapy with the recurrence rate. In the multivariate analysis only multifocality ( , HR 5.7) was a significant risk factor for the recurrence rate. Conclusions. Our results indicate that tumour multifocality is an independent predictor of relapse but neither the tumour size nor postsurgical 131I therapy.