TY - JOUR A2 - Pantos, Constantinos AU - Safer, Joshua D. PY - 2013 DA - 2013/03/20 TI - Thyroid Hormone and Wound Healing SP - 124538 VL - 2013 AB - Although thyroid hormone is one of the most potent stimulators of growth and metabolic rate, the potential to use thyroid hormone to treat cutaneous pathology has never been subject to rigorous investigation. A number of investigators have demonstrated intriguing therapeutic potential for topical thyroid hormone. Topical T3 has accelerated wound healing and hair growth in rodents. Topical T4 has been used to treat xerosis in humans. It is clear that the use of thyroid hormone to treat cutaneous pathology may be of large consequence and merits further study. This is a review of the literature regarding thyroid hormone action on skin along with skin manifestations of thyroid disease. The paper is intended to provide a context for recent findings of direct thyroid hormone action on cutaneous cells in vitro and in vivo which may portend the use of thyroid hormone to promote wound healing. SN - 2090-8067 UR - https://doi.org/10.1155/2013/124538 DO - 10.1155/2013/124538 JF - Journal of Thyroid Research PB - Hindawi Publishing Corporation KW - ER -