Table of Contents Author Guidelines Submit a Manuscript
Journal of Thyroid Research
Volume 2013 (2013), Article ID 182472, 15 pages
Review Article

Thyroid Autoantibodies in Pregnancy: Their Role, Regulation and Clinical Relevance

Thyroid Research Unit, Mount Sinai School of Medicine and James J. Peters VA Medical Center, 130 West Kingsbridge Road, Bronx, New York, NY 10468, USA

Received 1 August 2012; Revised 11 March 2013; Accepted 20 March 2013

Academic Editor: Elizabeth N. Pearce

Copyright © 2013 Francis S. Balucan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Autoantibodies to thyroglobulin and thyroid peroxidase are common in the euthyroid population and are considered secondary responses and indicative of thyroid inflammation. By contrast, autoantibodies to the TSH receptor are unique to patients with Graves' disease and to some patients with Hashimoto's thyroiditis. Both types of thyroid antibodies are useful clinical markers of autoimmune thyroid disease and are profoundly influenced by the immune suppression of pregnancy and the resulting loss of such suppression in the postpartum period. Here, we review these three types of thyroid antibodies and their antigens and how they relate to pregnancy itself, obstetric and neonatal outcomes, and the postpartum.