Thyroid Autoantibodies in Pregnancy: Their Role, Regulation and Clinical Relevance

Table 3

Sensitivity, specificity, and positive predictive values of thyroid autoantibodies when sampling done at the different times in pregnancy and post-partum adapted from Premawardhana et al. The positive predictive value of thyroid antibodies in predictive post-partum thyroid disease [117].

Investigator	Antibody	Ab-positive subjects (Ab-negative subjects with PPTD)	Sampling time—(pp) postpartum in months	Sensitivity	Specificity	PPV
Jansson	Micro	44 (7)	2–5	0.77	0.95	0.52
Amino	Micro	61 (1)	3	0.89	0.92	0.4
Lervang	Micro	38 (3)	3	0.87	0.97	0.53
Vargas	Micro	41*	Delivery	0.45	0.95	0.63
Vargas	Micro	54 (11)	2–4	0.76	0.91	0.65
Vargas	Micro	69 (8)	5–7	0.86	0.9	0.68
Pop	Micro	15 (6)	Trimester 3	0.71	0.92	0.52
Kuijpens	TPO	31 (5)	Trimesters 1/3	0.67	0.93	0.31
Kent	TPO	55 (31)	6	0.64	0.95	0.64
Kent	Micro	40 (46)	6	0.46	0.98	0.78
Sakaihara	Micro/Tg	50 (65)	Early pp-1	0.14	0.88	0.07
			Early pp-3	0.37	0.90	0.21
Solomon	Micro	55*	Delivery			0.73
Nohr	TPO	66*	Trimester 1	—	—	0.55
Premawardhana	TPO	308 (0)	Early pregnancy	1.00	0.62	0.48
			Early Postpartum	1.00	0.41	0.48

Sensitivity is defined as the number of true positives as a proportion of the sum of the number of true positives and false negatives. Specificity, defined as the number of true negatives as a proportion of the sum of the false positives and true negatives. Positive predictive value (PPV) is defined as the number of true-positives as a proportion of the sum of true and false positives.
∗Unknown or not included.