Table 3: Sensitivity, specificity, and positive predictive values of thyroid autoantibodies when sampling done at the different times in pregnancy and post-partum adapted from Premawardhana et al. The positive predictive value of thyroid antibodies in predictive post-partum thyroid disease [117].

InvestigatorAntibodyAb-positive subjects (Ab-negative subjects with PPTD)Sampling time—(pp) postpartum in months SensitivitySpecificityPPV

JanssonMicro44 (7)2–50.770.950.52
AminoMicro61 (1)30.890.920.4
LervangMicro38 (3)30.870.970.53
VargasMicro41*Delivery0.450.950.63
VargasMicro54 (11)2–40.760.910.65
VargasMicro69 (8)5–70.860.90.68
PopMicro15 (6)Trimester 30.710.920.52
KuijpensTPO31 (5)Trimesters 1/30.670.930.31
KentTPO55 (31)60.640.950.64
KentMicro40 (46)60.460.980.78
SakaiharaMicro/Tg50 (65)Early pp-10.140.880.07
Early pp-30.370.900.21
SolomonMicro55*Delivery0.73
NohrTPO66*Trimester 1 0.55
PremawardhanaTPO308 (0)Early pregnancy1.000.620.48
Early Postpartum1.000.410.48

Sensitivity is defined as the number of true positives as a proportion of the sum of the number of true positives and false negatives. Specificity, defined as the number of true negatives as a proportion of the sum of the false positives and true negatives. Positive predictive value (PPV) is defined as the number of true-positives as a proportion of the sum of true and false positives.
Unknown or not included.