Table of Contents Author Guidelines Submit a Manuscript
Journal of Thyroid Research
Volume 2013, Article ID 312104, 5 pages
http://dx.doi.org/10.1155/2013/312104
Review Article

Thyroid Hormone and Tissue Repair: New Tricks for an Old Hormone?

Department of Pharmacology, University of Athens, 75 Mikras Asias Avenue, Goudi, 11527 Athens, Greece

Received 1 November 2012; Accepted 26 January 2013

Academic Editor: Giorgio Iervasi

Copyright © 2013 Iordanis Mourouzis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Pantos, I. Mourouzis, and D. V. Cokkinos, “Thyroid hormone and cardiac repair/regeneration: from Prometheus myth to reality?” Canadian Journal of Physiology and Pharmacology, vol. 90, no. 8, pp. 977–987, 2012. View at Google Scholar
  2. J. F. Gudernatsch, “Feeding Experiments on tadpoles - I. The influence of specific organs given as food on growth and differentiation. A contribution to the knowledge of organs with internal secretion,” Archiv für Entwicklungsmechanik der Organismen, vol. 35, no. 3, pp. 457–483, 1912. View at Publisher · View at Google Scholar · View at Scopus
  3. D. L. Berry, C. S. Rose, B. F. Remo, and D. D. Brown, “The expression pattern of thyroid hormone response genes in remodeling tadpole tissues defines distinct growth and resorption gene expression programs,” Developmental Biology, vol. 203, no. 1, pp. 24–35, 1998. View at Publisher · View at Google Scholar · View at Scopus
  4. J. D. Furlow and E. S. Neff, “A developmental switch induced by thyroid hormone: xenopus laevis metamorphosis,” Trends in Endocrinology and Metabolism, vol. 17, no. 2, pp. 40–47, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. J. D. Furlow, H. Y. Yang, M. Hsu et al., “Induction of Larval tissue resorption in Xenopus laevis tadpoles by the thyroid hormone receptor agonist GC-1,” The Journal of Biological Chemistry, vol. 279, no. 25, pp. 26555–26562, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. B. Shi, L. Fu, S. C. V. Hsia, A. Tomita, and D. Buchholz, “Thyroid hormone regulation of apoptotic tissue remodeling during anuran metamorphosis,” Cell Research, vol. 11, no. 4, pp. 245–252, 2001. View at Google Scholar · View at Scopus
  7. C. Pantos, I. Mourouzis, and D. V. Cokkinos, “New insights into the role of thyroid hormone in cardiac remodeling: time to reconsider?” Heart Failure Reviews, vol. 16, no. 1, pp. 79–96, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. C. Pantos, I. Mourouzis, and D. V. Cokkinos, “Rebuilding the post-infarcted myocardium by activating “physiologic” hypertrophic signaling pathways: the thyroid hormone paradigm,” Heart Failure Reviews, vol. 15, no. 2, pp. 143–154, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Pantos, I. Mourouzis, G. Galanopoulos et al., “Thyroid hormone receptor 1 downregulation in postischemic heart failure progression: the potential role of tissue hypothyroidism,” Hormone and Metabolic Research, vol. 42, no. 10, pp. 718–724, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. V. S. Peter and M. C. Peter, “The interruption of thyroid and interrenal and the inter-hormonal interference in fish: does it promote physiologic adaptation or maladaptation?” General and Comparative Endocrinology, vol. 174, no. 3, pp. 249–258, 2012. View at Google Scholar
  11. V. S. Peter, E. K. Joshua, S. E. Wendelaar Bonga, and M. C. S. Peter, “Metabolic and thyroidal response in air-breathing perch (Anabas testudineus) to water-borne kerosene,” General and Comparative Endocrinology, vol. 152, no. 2-3, pp. 198–205, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. K. E. Hunt, C. Innis, and R. M. Rolland, “Corticosterone and thyroxine in cold-stunned Kemp's ridley sea turtles (Lepidochelys kempii),” Journal of Zoo and Wildlife Medicine, vol. 43, no. 3, pp. 479–493, 2012. View at Google Scholar
  13. B. Eber, M. Schumacher, W. Langsteger et al., “Changes in thyroid hormone parameters after acute myocardial infarction,” Cardiology, vol. 86, no. 2, pp. 152–156, 1995. View at Google Scholar · View at Scopus
  14. L. Friberg, S. Werner, G. Eggertsen, and S. Ahnve, “Rapid down-regulation of thyroid hormones in acute myocardial infarction: is it cardioprotective in patients with angina?” Archives of Internal Medicine, vol. 162, no. 12, pp. 1388–1394, 2002. View at Google Scholar · View at Scopus
  15. I. Lymvaios, I. Mourouzis, D. V. Cokkinos, M. A. Dimopoulos, S. T. Toumanidis, and C. Pantos, “Thyroid hormone and recovery of cardiac function in patients with acute myocardial infarction: a strong association?” European Journal of Endocrinology, vol. 165, no. 1, pp. 107–114, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Pantos, I. Mourouzis, T. Saranteas et al., “Acute T3 treatment protects the heart against ischemia-reperfusion injury via TRα1 receptor,” Molecular and Cellular Biochemistry, vol. 353, no. 1-2, pp. 235–241, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. C. Pantos, I. Mourouzis, T. Saranteas et al., “Thyroid hormone improves postischaemic recovery of function while limiting apoptosis: a new therapeutic approach to support hemodynamics in the setting of ischaemia-reperfusion?” Basic Research in Cardiology, vol. 104, no. 1, pp. 69–77, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Shulga, A. Blaesse, K. Kysenius et al., “Thyroxin regulates BDNF expression to promote survival of injured neurons,” Molecular and Cellular Neuroscience, vol. 42, no. 4, pp. 408–418, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Hiroi, H. H. Kim, H. Ying et al., “Rapid nongenomic actions of thyroid hormone,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 38, pp. 14104–14109, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Fernandez, A. Giuliani, S. Pirondi et al., “Thyroid hormone administration enhances remyelination in chronic demyelinating inflammatory disease,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 46, pp. 16363–16368, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. I. Papakostas, I. Mourouzis, K. Mourouzis, G. Macheras, E. Boviatsis, and C. Pantos, “Functional effects of local thyroid hormone administration after sciatic nerve injury in rats,” Microsurgery, vol. 29, no. 1, pp. 35–41, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. P. A. Panaite and I. Barakat-Walter, “Thyroid hormone enhances transected axonal regeneration and muscle reinnervation following rat sciatic nerve injury,” Journal of Neuroscience Research, vol. 88, no. 8, pp. 1751–1763, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. V. Fernández, I. Castillo, G. Tapia et al., “Thyroid hormone preconditioning: protection against ischemia-reperfusion liver injury in the rat,” Hepatology, vol. 45, no. 1, pp. 170–177, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. C. Ferreyra, F. O'Valle, J. M. Osorio et al., “Effect of preconditioning with triiodothyronine on renal ischemia/reperfusion injury and poly(ADP-ribose) polymerase expression in rats,” Transplantation Proceedings, vol. 41, no. 6, pp. 2073–2075, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. E. Erkan, A. Sakarcan, G. Haklar, and S. Yalcin, “Thyroxine prevents reoxygenation injury in isolated proximal tubule cells,” Pediatric Nephrology, vol. 18, no. 7, pp. 636–643, 2003. View at Google Scholar · View at Scopus
  26. P. M. Sutter, G. Thulin, M. Stromski et al., “Beneficial effect of thyroxin in the treatment of ischemic acute renal failure,” Pediatric Nephrology, vol. 2, no. 1, pp. 1–7, 1988. View at Google Scholar · View at Scopus
  27. C. Verga Falzacappa, C. Mangialardo, L. Madaro et al., “Thyroid hormone T3 counteracts STZ induced diabetes in mouse,” PLoS One, vol. 6, no. 5, Article ID e19839, 2011. View at Google Scholar
  28. C. Verga Falzacappa, E. Timperi, B. Bucci et al., “T3 preserves ovarian granulosa cells from chemotherapy induced apoptosis,” Journal of Endocrinology, vol. 215, pp. 281–289, 2012. View at Google Scholar
  29. M. Bhargava, M. R. Runyon, D. Smirnov et al., “Triiodo-L-thyronine rapidly stimulates alveolar fluid clearance in normal and hyperoxia-injured lungs,” American Journal of Respiratory and Critical Care Medicine, vol. 178, no. 5, pp. 506–512, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. C. I. Pantos, V. A. Malliopoulou, I. S. Mourouzis et al., “Long-term thyroxine administration protects the heart in a pattern similar to ischemic preconditioning,” Thyroid, vol. 12, no. 4, pp. 325–329, 2002. View at Google Scholar · View at Scopus
  31. J. A. Kuzman, A. M. Gerdes, S. Kobayashi, and Q. Liang, “Thyroid hormone activates Akt and prevents serum starvation-induced cell death in neonatal rat cardiomyocytes,” Journal of Molecular and Cellular Cardiology, vol. 39, no. 5, pp. 841–844, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. Y. F. Chen, S. Kobayashi, J. Chen et al., “Short term triiodo-l-thyronine treatment inhibits cardiac myocyte apoptosis in border area after myocardial infarction in rats,” Journal of Molecular and Cellular Cardiology, vol. 44, no. 1, pp. 180–187, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Dentice, A. Marsili, R. Ambrosio et al., “The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration,” The Journal of Clinical Investigation, vol. 120, no. 11, pp. 4021–4030, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Marsili, D. Tang, J. W. Harney et al., “Type II iodothyronine deiodinase provides intracellular 3, 5, 3′-triiodothyronine to normal and regenerating mouse skeletal muscle,” American Journal of Physiology, vol. 301, no. 5, pp. 818–824, 2011. View at Google Scholar
  35. K. Fukuyama, T. Ichiki, I. Imayama et al., “Thyroid hormone inhibits vascular remodeling through suppression of cAMP response element binding protein activity,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 26, no. 9, pp. 2049–2055, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. J. D. Safer, T. M. Crawford, and M. F. Holick, “A role for thyroid hormone in wound healing through keratin gene expression,” Endocrinology, vol. 145, no. 5, pp. 2357–2361, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. R. Kassem, Z. Liberty, M. Babaev et al., “Harnessing the skin-thyroid connection for wound healing: a prospective controlled trial in guinea pigs,” Journal of Clinical & Experimental Dermatology, vol. 37, no. 8, pp. 850–856, 2012. View at Google Scholar
  38. E. Kress, A. Rezza, J. Nadjar, J. Samarut, and M. Plateroti, “The thyroid hormone receptor-α (TRα) gene encoding TRα1 controls deoxyribonucleic acid damage-induced tissue repair,” Molecular Endocrinology, vol. 22, no. 1, pp. 47–55, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. J. Horacek, S. Dusilova Sulkova, M. Kubisova et al., “Thyroid hormone abnormalities in haemodialyzed patients: low triiodothyronine as well as high reverse triiodothyronine are associated with increased mortality,” Physiological Research, vol. 61, no. 5, pp. 495–501, 2012. View at Google Scholar
  40. C. V. Falzacappa, C. Mangialardo, S. Raffa et al., “The thyroid hormone T3 improves function and survival of rat pancreatic islets during in vitro culture,” Islets, vol. 2, no. 2, pp. 96–103, 2010. View at Google Scholar · View at Scopus
  41. H. G. Folkesson, A. Norlin, Y. Wang, P. Abedinpour, and M. A. Matthay, “Dexamethasone and thyroid hormone pretreatment upregulate alveolar epithelial fluid clearance in adult rats,” Journal of Applied Physiology, vol. 88, no. 2, pp. 416–424, 2000. View at Google Scholar · View at Scopus