Mechanisms of L-Triiodothyronine-Induced Inhibition of Synaptosomal Na⁺-K⁺-ATPase Activity in Young Adult Rat Brain Cerebral Cortex

Figure 3

Effect of T₃ on synaptosomal Na⁺-K⁺-ATPase activity and its modulation by a β-adrenergic receptor agonist (ISO) and a β-adrenergic receptor antagonist (PROP) in vitro. A half-maximally effective dose of T₃ (1 nM) was chosen from the dose-response curve for T₃ in Figure 1. The data are represented as mean ± SEM of five separate experiments taking six animals in each group. ^a𝑃<0.001, compared to the control group. ^b𝑃<0.001 and ^c𝑃<0.05, compared to T₃ (1 nM) + PROP (100 nM) group (one-way ANOVA followed by Newman-Keuls test). The vertical lines denote SEM.