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Journal of Thyroid Research
Volume 2013, Article ID 481287, 8 pages
Review Article

Thyroid and Aging or the Aging Thyroid? An Evidence-Based Analysis of the Literature

1Department of Endocrinology, Gateshead Health NHS Foundation NHS Trust, UK
2Institute of Genetic Medicine, Newcastle University, UK

Received 14 June 2013; Accepted 7 August 2013

Academic Editor: Glenn D. Braunstein

Copyright © 2013 Naveen Aggarwal and Salman Razvi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Thyroid hormone production, metabolism, and action change with aging. The reference ranges for serum thyrotropin and thyroid hormones are derived mainly from younger populations. Thus, the prevalence of subclinical thyroid dysfunction is increased greatly in the elderly. However, it is unclear whether mild thyroid dysfunction in the elderly is associated with adverse outcomes. In this review, we discuss current evidence-based literature on thyroid function in the elderly and whether subclinical thyroid dysfunction in the elderly should be treated.