Trimester-Specific Reference Ranges for Thyroid Hormones in Iranian Pregnant Women

Table 3

Summary of worldwide studies reporting trimester-specific reference intervals for TSH during pregnancy.

Study	Country	Sample size and Design	Centiles’ used	TSH reference intervals
				1st trimester	2nd trimester	3rd trimester
Panesar et al. [12], 2001	China	343; cohort	2.5th, 97.5th	𝑛=158; 0.03–2.3	𝑛=117; 0.03–3.1	𝑛=76; 0.13–3.5
Soldin et al. [6], 2007	USA	261; cross-sectional	2.5th, 97.5th	𝑛=71; 0.24–2.99	𝑛=83; 0.46–2.95	𝑛=62; 0.43–2.78
Stricker et al. [15], 2007	Switzerland	2272; cross-sectional	2.5th, 97.5th	𝑛=783; 0.09–2.82	𝑛=528; 0.2–2.79	𝑛=501; 0.31–2.9
Marwaha et al. [16], 2008	India	541; cross-sectional	5th, 95th	𝑛=107; 0.6–5	𝑛=137; 0.43–5.78	𝑛=87; 0.74–5.7
Bocos-Terraz et al. [17], 2009	Spain	1198; cross-sectional	2.5th, 97.5th	𝑛=481; 0.03–2.65	𝑛=243; 0.12–2.64	𝑛=297; 0.23–3.56
Yu et al. [14], 2010	China	538; cohort	2.5th, 97.5th	𝑛=301; 0.02–3.65	𝑛=301; 0.36–3.46	𝑛=301; 0.44–5.04
Yan et al. [18], 2011	China	505; cross-sectional	2.5th, 97.5th	𝑛=168; 0.03–4.51	𝑛=168; 0.05–4.5	𝑛=169; 0.47–4.54
Azizi et. al, 2012 [19]	Iran	261; cohort	5th, 95th	𝑛=216; 0.2–3.9	𝑛=216; 0.5–4.1	𝑛=216; 0.6–4.1
Haddow et al. [20], 2004	USA	1126; cohort	5th, 95th	𝑛=1005; 0.08–2.73	𝑛=1005; 0.39–2.70	—
Dhatt et al. [21], 2006	United Arab Emirates	1140; cross-sectional	—	United Arabs; 0.06–8.3, 𝑛=97; other Arabs 0.04–9.3, 𝑛=122; Asians; 0.12–7.4, 𝑛=79	United Arabs; 0.17–5.9; other Arabs; 0.23–5.7; Asians; 0.3–5.5	—
Lambert-Messerlian et al. [22], 2008	USA	9562; cohort	98th, 2th	𝑛=9562; 0.13–4.15	𝑛=9562; 0.36–3.77	—
Santiago et al. [23], 2011	Spain	429; cross-sectional	97th, 3th	𝑛=279; 0.23–4.18	𝑛=210; 0.36–3.89	—
Karakosta et al. [24], 2011	Greece	425; cohort	2.5th, 97.5th	𝑛=143; 0.05–2.53	𝑛=260; 0.18–2.73	—