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Journal of Thyroid Research
Volume 2014 (2014), Article ID 892573, 6 pages
http://dx.doi.org/10.1155/2014/892573
Clinical Study

Weight Gain and Serum TSH Increase within the Reference Range after Hemithyroidectomy Indicate Lowered Thyroid Function

1Department of Otorhinolaryngology-Head and Neck Surgery, Koege Hospital, Region Zealand, 4600 Koege, Denmark
2Department of Clinical Pathology, Naestved Hospital, Region Zealand, 4700 Naestved, Denmark
3Department of Clinical Biochemistry, Naestved Hospital, Region Zealand, 4700 Naestved, Denmark
4Department of Gynecology and Obstetrics, Naestved Hospital, Region Zealand, 4700 Naestved, Denmark
5Department of Internal Medicine, Naestved Hospital, Region Zealand, 4700 Naestved, Denmark
6University of Southern Denmark, 5230 Odense, Denmark

Received 22 December 2013; Accepted 27 April 2014; Published 14 May 2014

Academic Editor: Massimo Tonacchera

Copyright © 2014 Tina Toft Kristensen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Weight gain is frequently reported after hemithyroidectomy but the significance is recently discussed. Therefore, the aim of the study was to examine changes in body weight of hemithyroidectomized patients and to evaluate if TSH increase within the reference range could be related to weight gain. Methods. In a controlled follow-up study, two years after hemithyroidectomy for benign euthyroid goiter, postoperative TSH and body weight of 28 patients were compared to preoperative values and further compared to the results in 47 matched control persons, after a comparable follow-up period. Results. Two years after hemithyroidectomy, median serum TSH was increased over preoperative levels (1.23 versus 2.08 mIU/L, ) and patients had gained weight (75.0 versus 77.3 kg, ). Matched healthy controls had unchanged median serum TSH (1.70 versus 1.60 mIU/L, ) and weight (69.3 versus 69.3 kg, ). Patients on thyroxin treatment did not gain weight. TSH increase was significantly correlated with weight gain ( , ). Conclusion. Two years after hemithyroidectomy for benign euthyroid goiter, thyroid function is lowered within the laboratory reference range. Weight gain of patients who are biochemically euthyroid after hemithyroidectomy may be a clinical manifestation of a permanently decreased metabolic rate.