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Journal of Thyroid Research
Volume 2017, Article ID 9536479, 4 pages
Research Article

Outcome, Pain Perception, and Health-Related Quality of Life in Patients Submitted to Percutaneous Ethanol Injection for Simple Thyroid Cysts

1Division of Endocrinology, “V. Fazzi” Hospital, Piazza F. Muratore, 73100 Lecce, Italy
2Division of Pathology, “V. Fazzi” Hospital, Piazza F. Muratore, 73100 Lecce, Italy

Correspondence should be addressed to Roberto Negro; ti.orebil@orgen.rd

Received 29 April 2017; Accepted 29 May 2017; Published 9 July 2017

Academic Editor: Massimo Tonacchera

Copyright © 2017 Roberto Negro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Thyroid cysts are usually benign lesions that when voluminous may induce cosmetic concerns or local discomfort. Percutaneous ethanol injection (PEI) has been demonstrated to be effective for shrinkage of such cysts. In this retrospective study, we evaluated the efficacy, pain perception, and health-related quality of life (HRQL) in patients submitted to PEI for pure cystic lesions. We reviewed the data of 101 patients who underwent ≤3 PEI. In the whole group of patients, the volume reduction was 66% after the first, 74.4% after the second, and 79.4% after the third PEI treatment. 55.4% had a cystic volume ≤ 10 ml; 85.7% of cysts ≤ 10 ml were cured by just one PEI. The number of PEI was significantly higher in the >30.0 ml group; this latter group obtained the smallest percent reduction versus baseline after the first PEI when compared with smaller cysts. The sensation of pain reported during PEI was absent in 78.3% of cases, and HRQL significantly improved from pre- to the posttreatment. PEI is a safe and effective technique for pure cystic lesions. In addition, HRQL significantly improves, providing a further support for this procedure.