| | Author, year | Medical center | Reference | Study design | Patients | EBRT technique
(target volumes and doses) |
| | O’Connell et al., 1994 | Royal Marsden Hospital, London, UK | [19] | Retrospective | 11 | Bilateral neck and superior mediastinum with 60Co photons or 5 MV photons via AP/PA portals (60 Gy/30 daily fraction) or neck and superior mediastinum with 20 and 35 MeV electron beams, respectively (75 Gy/30 daily fraction) |
| | Meadows et al., 2006 | University of Florida Health Science Center, USA | [20] | Retrospective | 20 | Thyroid bed, cervical lymph nodes, upper mediastinum with photons via 3-field (anterior field of 45 Gy, opposed lateral fields with bolus to boost the final tumor dose) or thyroid bed, cervical lymph nodes, upper mediastinum with IMRT (64.9 Gy at 1.8 to 2.0 Gy/daily fraction) |
| | Kim et al., 2010 | Center for Thyroid Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea | [21] | Retrospective | 15 | Limited field: recurrent tumor bed and positive nodal area via 3DCRT or IMRT (median total dose of 62.5 Gy at 1.8 to 2.5 Gy/daily fraction) or elective field: recurrent tumor bed and regional nodal areas in the cervical neck and upper mediastinum via 3DCRT or IMRT (median total dose of 50 Gy and a median dose of 62.5 Gy to boost tumor bed and positive nodal area at 1.8 to 2.5 Gy/daily fraction) |
| | Romesser et al., 2014 | Memorial Sloan Kettering Cancer Center, New York, USA | [5] | Retrospective | 36 | Low-risk areas to 54 Gy; high risk areas to 60 Gy; close or microscopically positive margins to 66 Gy and areas of gross disease to 70 Gy (total median dose of 66.3 Gy in a median of 33 fractions) via IMRT (majority of cases) |
| | Current series | Bologna University, Bologna, Italy | — | Pilot | 16 | FDG-PET positive areas to 66 Gy, ipsilateral lymph nodes to 60 Gy, contralateral nodes to 54 Gy, in 30 fractions via IMRT-SIB technique |
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