Research Article
RET Proto-Oncogene Mutational Analysis in 45 Iranian Patients Affected with Medullary Thyroid Carcinoma: Report of a New Variant
Table 2
Variants according to in silico analysis.
| ā | Variant | InterVar | PolyPhen2 | Mutation taster | SIFT | MEN2 database | Report |
| 1 | p.H658R | Uncertain significance | Benign with 0.006 score:Sensitivity 0.97Specificity 0.75 | Disease causing | Tolerated (SIFT score 0.5) | ā | Novel | 2 | p.V648I | Likely benign | Benign with 0.006 score:Sensitivity 0.97Specificity 0.75 | Disease causing (NMD, amino acid sequence change, protein features might be affected, and splice site changes) | Tolerated (SIFT score 0.43) | Uncertain | [9] (2002) |
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