Association of Polygenetic Risk Scores Related to Immunity and Inflammation with Hyperthyroidism Risk and Interactions between the Polygenetic Scores and Dietary Factors in a Large Cohort

Figure 2

Adjusted odds ratio (ORs) and 95% confidence intervals (CIs) of the PRSs of 5- and 6-SNP models generated assessing gene-gene interactions associated with hyperthyroidism risk. The best GMDR models with 6 SNPs and 7 SNPs were calculated by the summation of the number of risk alleles of six and seven SNPs, and the calculated PRSs were divided into three categories (0–3, 4–6, and ≥7) and (0–4, 5–7, and ≥8), respectively, as the low PRS, medium PRS, and high PRS groups. The adjusted OR was analyzed by logistic regression with the covariates including age, gender, residence areas, initial menstruation age, menopause, pregnancy experience, income, education, energy intake, seaweed intake, smoking status, physical activity, WBC counts, alcohol intake, autoimmune diseases, and survey year. The reference group was the low PRS in logistic regression. Red and blue boxes indicated the adjusted ORs for five SNPs and six SNPs, respectively, and the lines through red and blue boxes indicated 95% CIs.