Research Article
Thyroid Signaling Biomarkers in Female Symptomatic Hypothyroid Patients on Liothyronine versus Levothyroxine Monotherapy: A Randomized Crossover Trial
Table 2
Biochemical and hormonal parameters reflecting thyroid hormone signaling.
| | | Baseline (n = 59) | After 12 weeks on LT4 (n = 48) | After 12 weeks on LT3 (n = 48) | LT4 vs. LT3 (n = 47) | | Result | Result | P Value | Result | P Value | P Value |
| | TSH (mU/L) | 0.64 (0.26–1.60) | 0.61 (0.25–1.20) | 0.155 | 1.33 (0.47–2.26) | 0.232 | 0.018 | | FT4 (pmol/L) | 16.8 (14.7–19.0) | 16.0 (14.4–17.3) | 0.226 | 3.1 (3.1–4.0) | <0.001 | <0.001 | | FT3 (pmol/L) | 4.4 (3.8–4.9) | 4.2 (3.9–4.6) | 0.520 | 4.6 (4.0–5.0) | 0.033 | 0.008 | | SHBG (nmol/L) | 59.0 (40.0–83.0) | 56.0 (39.3–75.0) | 0.888 | 75.0 (49.5–97.0) | <0.001 | 0.001 | | rT3 (nmol/L) | 0.50 (0.43–0.59) | 0.46 (0.38–0.58) | 0.029 | 0.03 (0.03–0.05) | <0.001 | <0.001 | | TC (mmol/L) | 5.1 (4.1–5.7) | 5.1 (4.3–5.7) | 0.352 | 4.6 (3.9–5.6) | <0.001 | <0.001 | | LDL (mmol/L) | 3.2 (2.4–3.6) | 3.1 (2.6–3.7) | 0.903 | 2.8 (2.3–3.3) | <0.001 | <0.001 | | HDL (mmol/L) | 1.5 (1.3–1.7) | 1.5 (1.3–1.7) | 0.865 | 1.5 (1.2–1.7) | 0.003 | 0.005 | | NT pro-BNP (ng/L) | 50.0 (50.0–63.0) | 50.0 (50.0–58.8) | 0.696 | 52.0 (50.0–90.3) | 0.188 | 0.057 | | CTX (µg/L) | 0.36 (0.27–0.45) | 0.34 (0.24–0.46) | 0.623 | 0.38 (0.27–0.48) | 0.009 | 0.140 | | PINP (µg/L) | 46.7 (38.7–63.7) | 50.6 (40.3–71.3) | 0.087 | 50.9 (42.2–68.8) | 0.001 | 0.200 |
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Data are presented as median (interquartile range: 25–75%). TSH: thyroid-stimulating hormone (ref. range 0.5–3.6), FT4: free thyroxine (8.0–21.0), FT3: free triiodothyronine (2.8–7.0), SHBG: sex hormone-binding globulin (23–100), rT3: reverse triiodothyronine (0.14–0.54), TC: total cholesterol (3.3–6.9), LDL: low-density lipoprotein (1.9–4.8), HDL: high-density lipoprotein (1.0–2.7), NT pro-BNP: pro-B-type natriuretic peptide (<170), CTX: C-terminal telopeptide of type 1 collagen (≤0.57), PINP: procollagen type 1 N propeptide (11–94).
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