Journal of Thyroid Research

Advances in Graves’ Disease

Publishing date
30 May 2012
Submission deadline
30 Nov 2011

1Departamento de Endocrinología, Clinica Universidad de Navarra, Pamplona, Spain

2Division of Endocrinology and Metabolism, James J. Peters VA Medical Center, Mount Sinai School of Medicine, New York, NY, USA

3Endocrine Unit, Evgenidion-Hospital, University of Athens, Athens, Greece

4University Hospital of Wales, Heath Park, Cardiff, UK

Advances in Graves’ Disease


Graves' disease is the most common cause of hyperthyroidism. Despite the recent advances in medicine, the clinical management of this disease has changed very little over the last decades. However, in the past few years some progress has been made in unraveling the molecular mechanisms of the disease. In particular, our current knowledge about the genetic and autoimmune basis of Graves' disease has recently expanded dramatically. As a consequence, there are several molecular target therapies under development that would change the treatment of the disease. Some breakthroughs have also been found after investigation in the clinical arena. Therefore, it is conceivable that in the near future clinicians will be able to carry out new strategies in the management of this condition.

The objective of the present special issue is to include reviews and original research articles about the most recent advances in this area. Basic, translational, and clinical contributions are welcome. We invite authors to submit original research articles as well as review articles related to Graves' disease. Potential topics of interest include, but are not limited to:

  • Emerging mechanisms of disease:
    • Microchimerism
    • The TSH-R hinge region
    • Infection
    • New genetic insights
    • The interplay of genetics and environment in GD
    • The immunopathogenetic pathways of GD
  • Emerging therapeutic strategies:
    • Blocking TSH-R antibodies
    • Low-molecular-weight antagonists for TSH receptor
    • Immunomodulation: Rituximab and Ab inhibition
    • The various aspects of corticosteroid treatment of GO
    • The burgeoning role of Selenium in the treatment of GD and GO

Articles published in this special issue will not be subject to the journal's Article Processing Charges.

Before submission authors should carefully read over the journal's Author Guidelines, which are located at Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at according to the following timetable:


  • Special Issue
  • - Volume 2012
  • - Article ID 809231
  • - Editorial

Advances in Graves' Disease

Juan C. Galofré | Leonidas H. Duntas | ... | Terry F. Davies
  • Special Issue
  • - Volume 2012
  • - Article ID 182176
  • - Clinical Study

Changes of TSH-Stimulation Blocking Antibody (TSBAb) and Thyroid Stimulating Antibody (TSAb) Over 10 Years in 34 TSBAb-Positive Patients with Hypothyroidism and in 98 TSAb-Positive Graves’ Patients with Hyperthyroidism: Reevaluation of TSBAb and TSAb in TSH-Receptor-Antibody (TRAb)-Positive Patients

Nobuyuki Takasu | Mina Matsushita
  • Special Issue
  • - Volume 2012
  • - Article ID 525936
  • - Review Article

The Role of Thyrotrophin Receptor Antibody Assays in Graves’ Disease

C. Kamath | M. A. Adlan | L. D. Premawardhana
  • Special Issue
  • - Volume 2012
  • - Article ID 724382
  • - Review Article

Microchimerism in Graves' Disease

Juan C. Galofré
  • Special Issue
  • - Volume 2012
  • - Article ID 623852
  • - Review Article

New Genetic Insights from Autoimmune Thyroid Disease

Terry F. Davies | Rauf Latif | Xiaoming Yin
  • Special Issue
  • - Volume 2012
  • - Article ID 368536
  • - Research Article

Determinants of Extraocular Muscle Volume in Patients with Graves' Disease

Samer El-Kaissi | Jack R. Wall
  • Special Issue
  • - Volume 2012
  • - Article ID 736161
  • - Review Article

The Evolving Role of Selenium in the Treatment of Graves' Disease and Ophthalmopathy

Leonidas H. Duntas
  • Special Issue
  • - Volume 2012
  • - Article ID 302537
  • - Review Article

The Role of Oxidative Stress on the Pathogenesis of Graves' Disease

Miloš Žarković
  • Special Issue
  • - Volume 2012
  • - Article ID 768019
  • - Review Article

Atypical Clinical Manifestations of Graves' Disease: An Analysis in Depth

Mohamed Osama Hegazi | Sherif Ahmed
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