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Journal of Transplantation
Volume 2009, Article ID 103784, 3 pages
Case Report

Hepatitis B Associated Monoclonal Gammopathy That Resolved after Successful Liver Transplant

Section of Hepatology, Division of Gastroenterology, Department of Medicine, Methodist University Hospital, University of Tennessee Health Science Center, Memphis, TN 38163, USA

Received 3 December 2008; Accepted 14 January 2009

Academic Editor: Paul C. Kuo

Copyright © 2009 P. Sreenivasan and S. Nair. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Monoclonal gammopathy of undetermined significance (MGUS) has been most commonly associated with diseases like multiple myeloma, Waldenstrom's macroglobulinemia, primary systemic amyloidosis, HIV, and other lymphoproliferative disorders. There has been an isolated report of MGUS in patients coinfected with HIV and Hepatitis B, as the work by Amara et al. in 2006. Here, we report a case of IgA-kappa light chain gammopathy secondary to Hepatitis B infection, which resolved after liver transplantation. To our knowledge, this is the first reported case of M protein spike seen in the context of Hepatitis B infection only.