Persistence of Hepatitis C RNA in Liver Allografts Is Associated with Histologic Progression Independent of Serologic Viral Clearance
Table 3
Antiviral treatment duration and outcomes
collated by patient group, HCV genotype, timing of ISH assayed biopsy and
virologic response.
Group, genotype and case number
ISH Status
Treatment duration at ISH assay (months)
Total treatment duration (months)
Viral load response
HCV undetectable by 12 weeks
HCV undetectable by 24 weeks
Outcome
Group 1,
genotype 2 or 3
1
+
12
12
EVR
No
Yes
SVR
2
+
12
18
EVR
NA
Yes
SVR
3
+
21
26
RVR
Yes
SVR
4
+
14
37
EVR
Yes
On therapy
Group 1, genotype 1 or unknown*
5
+
4
18
EVR
No
Yes
Relapse
6
+
5
19
EVR
Yes
SVR
7*
+
9
18
EVR
Yes
SVR
8
+
14
21
No EVR
No
Yes
SVR
9
+
21
46
EVR
NA
Yes
SVR
10
+
13
22
EVR
Yes
SVR
Group 2,
genotype 2 or 3
11
7
11
RVR
Yes
SVR
12
9
9
No EVR
No
Yes
Relapse
Group 2, genotype 1 or unknown*
13
10
11
EVR
NA
Yes
SVR
14
8
12
EVR
NA
Yes
Relapse
15
6
11
RVR
Yes
SVR
16*
8
12
EVR
Yes
SVR
17
10
13
EVR
Yes
Relapse
18
14
14
EVR
NA
Yes
SVR
19
11
12
EVR
No
Yes
Relapse
20
20
33
No EVR
No
No
SVR
21
3
12
EVR
Yes
SVR
22
14
14
NA
NA
Yes
SVR
23
7
12
EVR
No
Yes
Relapse
24
13
17
EVR
No
Yes
SVR
25
12
13
EVR
Yes
Relapse
NA: Not available; EVR: Early virologic response; RVR: Rapid virologic response; SVR: Sustained viral response. *The patients that did not have a known genotype.
