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Journal of Transplantation
Volume 2009 (2009), Article ID 379082, 5 pages
http://dx.doi.org/10.1155/2009/379082
Clinical Study

FGF-23 Levels before and after Renal Transplantation

University Department of Nephrology, Hippokration General Hospital, 54642 Thessaloniki, Greece

Received 3 February 2009; Accepted 26 April 2009

Academic Editor: Bruce Kaplan

Copyright © 2009 Domniki Economidou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Phosphatonin fibroblast growth factor-23 (FGF-23) is involved in phosphate (P) excretion and vitamin D metabolism. Recently, FGF-23 has been suggested to be responsible for the hypophosphatemia and inappropriately low calcitriol levels observed after renal transplantation. We performed a prospective study to investigate FGF-23 levels in patients with end-stage renal disease before and after renal transplantation and their probable association with markers of bone and mineral metabolism. Intact FGF-23 levels were determined before and at 3, 6, and 12 months posttransplantation in 18 renal transplant recipients. Intact parathyroid hormone (iPTH), calcium (Ca), P, 25(OH)VitD, and 1,25 ( O H ) 2 VitD levels were measured at the same time periods. Renal threshold phosphate concentration ( T m P O 4 /GFR) was also calculated at 3, 6, and 12 months posttransplantation. The results showed that FGF-23 levels decreased by 89% 3 months posttransplantation (346 ± 146 versus 37 ± 9 pg/mL, 𝑃 < . 0 1 ) and remained stable throughout the study period. iPTH and P levels also decreased significantly after renal transplantation, while Ca and 1,25 ( O H ) 2 VitD increased. Pretransplantation FGF-23 was significantly correlated with P levels at 3 months posttransplantation ( 𝑃 < . 0 0 5 ). In conclusion, FGF-23 levels decrease dramatically after successful renal transplantation. Pre-transplantation FGF-23 correlate with P levels 3 months posttransplantation.