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Journal of Transplantation
Volume 2009, Article ID 597371, 4 pages
Case Report

Regression of Hypervascular Nodules in a Patient with Wilson's Disease Awaiting Liver Transplantation

Liver Transplant Unit and Radiology Department, Hôpital Cochin, Université Paris Descartes, 75679 Paris, France

Received 30 March 2009; Revised 23 July 2009; Accepted 29 August 2009

Academic Editor: Josep M. Grinyó

Copyright © 2009 Alcindo Pissaia Jr. et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This paper describes the regressive course over one year of hypervascular nodules in a patient with Wilson's disease. CT revealed multiple, enhancing nodules (up to 3 cm in diameter) detected in the liver in the early arterial phase after the administration of intravenous contrast material. Most of these nodules became isodense in the portal venous phase. After one year of efficient therapy combining d-penicillamine and zinc acetate, most of the nodules had disappeared, while the liver contours had become more regular. To our knowledge, the regression of large hypervascular nodules has not previously been reported in patients with Wilson's disease.