|
| Immunosuppressive agent | Target pathway |
|
| Pharmacological |
|
| Corticosteroids | (a) Inhibits cytokine transcription by antigen presenting cell |
| (b) Selective lysis of immature cortical thymocytes |
| Calcineurin inhibitors (cyclosporine/neoral and tacrolimus/Prograf/Fk506) | Inhibits Signal 2 transduction via T cell receptor |
| Mammalian Target of rapamycin inhibitors (sirolimus/rapamycin, everolimus) | Inhibits signal 3 transduction via IL-2 receptor |
| Azathioprine (Imuran) | Inhibits purine and DNA synthesis |
| Mycophenolic acid (cell cept) | Inhibits purine and DNA synthesis |
|
| Biological |
|
| Anti-CD3 monoclonal antibodies (OKT3) | (a) Causes depletion and receptor modulation in T cell |
| (b) Interferes with signal 1 |
| Antithymocyte globulin (ATG) | (a) Causes depletion and receptor modulation in T cells |
| (b) Interferes with signal 1, 2 and 3 |
| (c) Inhibits lymphocyte trafficking |
| Anti IL-2 alpha chain receptor antibodies (Basiliximab, Daclizumumab) | Inhibits T cell proliferation to IL-2 (signal 3) |
| Anti-CD52 monoclonal antibodies (campath 1-H) | Causes depletion of thymocytes, T cells, B cells (not plasma cells) and monocytes |
|
