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Journal of Transplantation
Volume 2010, Article ID 201918, 6 pages
http://dx.doi.org/10.1155/2010/201918
Clinical Study

Potential of Dried Blood Self-Sampling for Cyclosporine Monitoring in Transplant Outpatients

1Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, 04103 Leipzig, Germany
2Surgical Clinic and Policlinic II, University Hospital Leipzig, 04103 Leipzig, Germany

Received 8 February 2010; Revised 11 April 2010; Accepted 15 April 2010

Academic Editor: Edward H. Cole

Copyright © 2010 Alexander Benedikt Leichtle et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. B. Barnard, J. Thekkudan, S. Richardson et al., “Cyclosporine profiling with C2 and C0 monitoring improves outcomes after heart transplantation,” Journal of Heart and Lung Transplantation, vol. 25, no. 5, pp. 564–568, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Levy, P. Burra, A. Cavallari et al., “Improved clinical outcomes for liver transplant recipients using cyclosporine monitoring based on 2-hr post-dose levels (C2),” Transplantation, vol. 73, no. 6, pp. 953–959, 2002. View at Google Scholar · View at Scopus
  3. M. Cantarovich, J.-G. Besner, J. S. Barkun, E. Elstein, and R. Loertscher, “Two-hour cyclosporine level determination is the appropriate tool to monitor Neoral therapy,” Clinical Transplantation, vol. 12, no. 3, pp. 243–249, 1998. View at Google Scholar · View at Scopus
  4. A. Lindholm and B. D. Kahan, “Influence of cyclosporine pharmacokinetics, trough concentrations, and AUC monitoring on outcome after kidney transplantation,” Clinical Pharmacology and Therapeutics, vol. 54, no. 2, pp. 205–218, 1993. View at Google Scholar · View at Scopus
  5. S. Schubert, H. Abdul-Khaliq, H. B. Lehmkuhl et al., “Advantages of C2 monitoring to avoid acute rejection in pediatric heart transplant recipients,” Journal of Heart and Lung Transplantation, vol. 25, no. 6, pp. 619–625, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. P. D. Acott, “Home fingerprick sampling for immunosuppressant drug monitoring in pediatric renal transplant patients: commentary,” Nature Clinical Practice Nephrology, vol. 2, no. 6, pp. 304–305, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. U. Ceglarek, J. Lembcke, G. M. Fiedler et al., “Rapid simultaneous quantification of immunosuppressants in transplant patients by turbulent flow chromatography combined with tandem mass spectrometry,” Clinica Chimica Acta, vol. 346, no. 2, pp. 181–190, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. The R Development Core Team, R: A language and environment for statistical computing, R Foundation for Statistical Computing, Vienna, Austria, 2009.
  9. F. Andrews, “A graphical user interface for exploratory visualisation,” 2008, http://latticist.googlecode.com/.
  10. G. Merton, K. Jones, M. Lee, A. Johnston, and D. W. Holt, “Accuracy of cyclosporin measurements made in capillary blood samples obtained by skin puncture,” Therapeutic Drug Monitoring, vol. 22, no. 5, pp. 594–598, 2000. View at Publisher · View at Google Scholar · View at Scopus
  11. N. Yonan, R. Martyszczuk, A. Machaal, A. Baynes, and B. G. Keevil, “Monitoring of cyclosporine levels in transplant recipients using self-administered fingerprick sampling,” Clinical Transplantation, vol. 20, pp. 221–225, 2006. View at Google Scholar
  12. B. G. Keevil, D. P. Tierney, D. P. Cooper, M. R. Morris, A. Machaal, and N. Yonan, “Simultaneous and rapid analysis of cyclosporin A and creatinine in finger prick blood samples using liquid chromatography tandem mass spectrometry and its application in C2 monitoring,” Therapeutic Drug Monitoring, vol. 24, no. 6, pp. 757–767, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. M. J. Bogusz, E. A. Enazi, H. Hassan, J. Abdel-Jawaad, J. A. Ruwaily, and M. A. Tufail, “Simultaneous LC-MS-MS determination of cyclosporine A, tacrolimus, and sirolimus in whole blood as well as mycophenolic acid in plasma using common pretreatment procedure,” Journal of Chromatography B, vol. 850, no. 1-2, pp. 471–480, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Holub, K. Tuschl, R. Ratschmann et al., “Influence of hematocrit and localisation of punch in dried blood spots on levels of amino acids and acylcarnitines measured by tandem mass spectrometry,” Clinica Chimica Acta, vol. 373, no. 1-2, pp. 27–31, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. U. Ceglarek, B. Casetta, J. Lembcke, S. Baumann, G. M. Fiedler, and J. Thiery, “Inclusion of MPA and in a rapid multi-drug LC-tandem mass spectrometric method for simultaneous determination of immunosuppressants,” Clinica Chimica Acta, vol. 373, no. 1-2, pp. 168–171, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. N. J. A. Webb, D. Roberts, R. Preziosi, and B. G. Keevil, “Fingerprick blood samples can be used to accurately measure tacrolimus levels by tandem mass spectrometry,” Pediatric Transplantation, vol. 9, no. 6, pp. 729–733, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. L. S. Azevedo, R. Manrique, and E. Sabbaga, “Comparison of the determination of cyclosporin-A in blood samples collected on filter paper and by the ordinary technique,” Revista da Associação Médica Brasileira, vol. 41, no. 3, pp. 183–186, 1995. View at Google Scholar · View at Scopus