Prognostic Factors for Tumor Recurrence after a 12-Year, Single-Center Experience of Liver Transplantations in Patients with Hepatocellular Carcinoma

Table 2

Univariate analysis of factors affecting recurrence-free survival after OLT in patients with HCC.

Variables		3-yr survival	5-yr survival	P value
Gender	Female ($n=42$)	82%	82%	.1
	Male ($n=241$)	89%	87%
Age	$\le$ 60 years ($n=184$)	88%	87%	.9
	$>$ 60 years ($n=99$)	89%	85%
AFP $>$ 30 ng/mL at OLT	No ($n=201$)	92%	91%	$<$ .0001
	Yes ($n=78$)	76%	74%
Viral infection	HCV-positive ($n=152$)	85%	83%	.4
	HBV-positive ($n=70$)	88%	88%
	HCV, HBV-positive ($n=13$)	92%	92%
	HCV, HBV-negative ($n=48$)	98%	94%
Down-staging to MC	No ($n=243$)	89%	88%	.2
	Yes ($n=39$)	83%	79%
Preoperative MC	Fulfilled ($n=224$)	90%	89%	.07
	Not fulfilled ($n=59$)	81%	77%
Preoperative up-to-seven	Fulfilled ($n=267$)	88%	86%	.9
	Not fulfilled ($n=16$)	86%	86%
Pre-OLT treatments	No ($n=53$)	96%	94%	.05
	Yes ($n=222$)	86%	84%
Histological MC	Fulfilled ($n=208$)	94%	92%	$<$ .0001
	Not fulfilled ($n=75$)	73%	71%
Histological up-to-seven	Fulfilled ($n=249$)	91%	89%	$<$ .0001
	Not fulfilled ($n=34$)	69%	65%
Grading	G0–G2 ($n=143$)	96%	95%	$<$ .0001
	G3–G4 ($n=140$)	80%	78%
Microvascular invasion	No ($n=166$)	97%	96%	$<$ .0001
	Yes ($n=117$)	76%	73%
Macrovascular invasion	No ($n=280$)	88%	87%	.07
	Yes ($n=3$)	67%	67%
Post-OLT m-TOR inhibitors	No ($n=240$)	89%	87%	.2
	Yes ($n=43$)	81%	81%

OLT: orthotopic liver transplantation. HCC: hepatocellular carcinoma. AFP: alpha-fetoprotein. MC: Milan criteria. M-TOR: Mammalian Target Of Rapamycin.