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Journal of Transplantation
Volume 2011, Article ID 596801, 7 pages
http://dx.doi.org/10.1155/2011/596801
Clinical Study

Pancreas Transplantation: Does Age Increase Morbidity?

1Division of Transplantation, Department of Surgery, New York Presbyterian Hospital, Weill Cornell Medical College, 525 East 68th Street, P.O. Box 207, New York, NY 10021, USA
2Division of Nephrology, Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA

Received 14 January 2011; Revised 22 March 2011; Accepted 7 April 2011

Academic Editor: Waldo Concepcion

Copyright © 2011 Cheguevara Afaneh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Pancreas transplantation (PTx) is the only definitive intervention for type 1 diabetes. Medical advancements in diabetes care have led to an aging PTx candidate pool. We report our experience with patients ≥50 years of age undergoing PTx. Methods. We reviewed 136 consecutive PTx patients at our institution from 1996–2010; 17 were ≥50 years of age. We evaluated demographics, surgical complications, acute rejection (AR) rates, nonsurgical infections, and survival outcomes. Results. Demographic data was similar ( 𝑃 > . 0 5 ) between groups, excluding age. The two groups had comparable major and minor surgical complication rates ( 𝑃 = . 1 0 and 𝑃 = . 2 5 , resp.). The older group had a lower 1-year and overall AR rate ( 𝑃 = . 0 4 and 𝑃 = . 0 3 , resp.). The incidence of non-surgical infections and overall patient and graft survival was similar between groups ( 𝑃 > . 0 5 ). Conclusion. Older patients with type 1 diabetes are feasible candidates for PTx, as surgical morbidity, incidence of infections, and AR rates are low.