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Journal of Transplantation
Volume 2011, Article ID 803429, 6 pages
http://dx.doi.org/10.1155/2011/803429
Research Article

The Interleukin-6 Gene Promoter Polymorphism -174 and Atherosclerotic Events in Overweight Transplanted Patients

Jamal Bamoulid,1,2,3,4 Cécile Courivaud,1,2,3,4 Marina Deschamps,1,2,3,5 Béatrice Gaugler,1,2,3,5 Pierre Tiberghien,1,2,3,5,6 Jean-Marc Chalopin,1,2,3,4,6 Philippe Saas,1,2,3,5,6 and Didier Ducloux1,2,3,4,6

1INSERM, UMR645, 25020 Besançon, France
2Université de Franche-Comté, Faculté de Médecine et de Pharmacie, 25020 Besançon, France
3Institut Fédérative de Recherche, IFR133, 25000 Besançon, France
4CHU Saint Jacques, Department of Nephrology, Dialysis, and Renal Transplantation, 25030 Besançon, France
5EFS Bourgogne Franche-Comté, Plateforme de Biomonitoring, CIC-BT506, 25020 Besançon, France
6CHU Saint Jacques, CIC Biothérapie, CIC-BT 506, 25030 Besançon, France

Received 26 October 2010; Revised 1 February 2011; Accepted 14 March 2011

Academic Editor: Eric Thervet

Copyright © 2011 Jamal Bamoulid et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Chronic inflammation plays a pivotal role in atherosclerosis. We hypothesized that combining overweight and a greater genetic capacity to produce IL-6 predicted by IL-6 gene promoter polymorphism at position -174 (G→C) may allow to identify individuals exhibiting higher IL-6 and C-reactive protein (CRP) concentrations with a higher risk of atherosclerotic events (AE). The occurrence of AE was analyzed with respect to body mass index, IL-6 gene promoter polymorphism at position -174 (G→C), and other relevant risk factors, retrospectively, in 217 renal transplant recipients and, prospectively, in 132. Circulating IL-6 concentrations were closely related to BMI ( , ). In overweight patients, serum IL-6 concentration was found to be significantly lower in C carriers than in GG patients (4.2 [1.0–5.1] versus 7.3 pg/mL [4.4–100]; ). The incidence of AE was higher in overweight GG patients (29.5% versus 10.1%; ). In multivariate analysis, overweight-GG had an increased risk to develop AE (HR 2.96 [95% CI 1.09–8.04], in the retrospective cohort, and HR 2.99 [95% CI 0.92–9.33], in the prospective cohort). All these data are consistent with a role for both genetic and environmental determinants of inflammation (white adipose tissue mass) in the development of AE in renal transplanted patients.