Attempted Depletion of Passenger Leukocytes by Irradiation in Pigs

Figure 1

Cell counts in the blood of pigs receiving (a) low-dose or (b) high-dose irradiation. (a) Mean total WBC, T and B cell counts (left upper), and CD4⁺ and CD8⁺ cell counts (left lower) of 3 pigs receiving WBI of 700 cGy and a further 800 cGy with both kidneys shielded. (b) Mean total WBC, T and B cell counts (right upper), and CD4⁺ and CD8⁺ cell counts (right lower) of 3 pigs receiving WBI of 700 cGy and a further 1300 cGy with both kidneys shielded. Although T and B cell counts decreased rapidly to <100 cells/mm³ within 24 h after irradiation, the total WBC count did not reach such a low number for 72 h. The remaining WBCs were largely polymorphonuclear neutrophils.

(a)

(b)