Xenotransplantation of Human Neural Progenitor Cells to the Subretinal Space of Nonimmunosuppressed Pigs

Figure 3

Xenografted human NPCs within the porcine retina. Donor cells were identified via anti-human nuclear immunolabeling and FITC-conjugated secondary (green). In addition to abundant cells within the subretinal space (top of image), labeled profiles were also evident within specific layers of the host retina, including the outer nuclear layer (horizontal arrow) and the inner plexiform layer (upward pointing arrows). In the latter case, the donor cells appear to be specifically positioned within a relatively restricted sublaminar zone. Survival = 12 days.