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Journal of Transplantation
Volume 2011, Article ID 970421, 11 pages
http://dx.doi.org/10.1155/2011/970421
Review Article

ABO Incompatible Kidney Transplantation—Current Status and Uncertainties

Division of Transplant Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, No. 50 Ilwon-dong, Kangnam-ku, Seoul 135-710, Republic of Korea

Received 14 June 2011; Accepted 23 October 2011

Academic Editor: Eric Thervet

Copyright © 2011 Milljae Shin and Sung-Joo Kim. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In the past, ABO blood group incompatibility was considered an absolute contraindication for kidney transplantation. Progress in defined desensitization practice and immunologic understanding has allowed increasingly successful ABO incompatible transplantation during recent years. This paper focused on the history, disserted outcomes, desensitization modalities and protocols, posttransplant immunologic surveillance, and antibody-mediated rejection in transplantation with an ABO incompatible kidney allograft. The mechanism underlying accommodation and antibody-mediated injury was also described.