Use of Cyclosporine in Uterine Transplantation

Table 2

Effect of CsA on leucocytes [23].

Cell type	Effect
B lymphocyte	(i) ↓ cytokine production by T cells leading to inhibition of proliferation
	(ii) B-cell activation leading to induction of apoptosis
	(iii) Ligation of immunoglobulin leading to inhibition of proliferation
T lymphocytes	(i) ↓ in IL-2/3/4, GM-CSF, TNF-𝛼 expression
	(ii) ↓ levels of IL-2 resulting in ↓ production of T cells
	(iii) ↓ level of Ca^2+-dependent exocytosis of granule-associated esterases
Granulocyte	(i) ↓ level of Ca^2+-dependent exocytosis of granule-associated esterases