Clinical Study

Estimation of Abbreviated Cyclosporine A Area under the Concentration-Time Curve in Allogenic Stem Cell Transplantation after Oral Administration

Figure 2

Comparison of the full cyclosporine (CsA) A U C 0 - 1 2 h and values estimated using 6 regression models: (a) model using trough concentration ( 𝑅 2 = 0 . 3 9 1 ), (b) model using concentration at 2 hours after dosing ( 𝑅 2 = 0 . 8 4 8 ), (c) model using concentration at 4 hours after dosing ( 𝑅 2 = 0 . 8 9 7 ), (d) model using concentrations at 2 and 4 hours after dosing ( 𝑅 2 = 0 . 9 3 0 ), (e) model using concentrations at 0.5, 2 and 4 hours after dosing ( 𝑅 2 = 0 . 9 4 3 ), and (f) model using concentrations at 2, 4, 6 and 8 hours after dosing ( 𝑅 2 = 0 . 9 6 5 ).
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(a)
342701.fig.002b
(b)
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(c)
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(d)
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(e)
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(f)