Journal of Transplantation

Clinical Study

Estimation of Abbreviated Cyclosporine A Area under the Concentration-Time Curve in Allogenic Stem Cell Transplantation after Oral Administration

Table 4

Multiple linear regression analysis of the correlation between the estimated cyclosporine (CsA) A U C 0 - 1 2 h and full hours CsA AUC ( 𝑁 = 3 0 ).
ModelsSampling time (h)Model equation for abbreviated AUCPearson 𝑅 2
12, 4 A U C 0 - 1 2 h = 0 . 8 2 + 2 . 7 6 6 × 𝐶 2 + 3 . 4 0 9 × 𝐶 4 0.930
20, 2 A U C 0 - 1 2 h = 0 . 6 9 7 + 7 . 8 5 × 𝐶 0 + 2 . 9 2 6 × 𝐶 2 0.797
32, 6 A U C 0 - 1 2 h = 0 . 4 8 3 + 2 . 7 5 2 × 𝐶 2 + 6 . 5 8 × 𝐶 6 0.908
42, 3 A U C 0 - 1 2 h = 0 . 9 3 6 + 2 . 0 1 2 × 𝐶 2 + 3 . 4 0 5 × 𝐶 3 0.903
53, 4 A U C 0 - 1 2 h = 1 . 3 6 4 + 3 . 6 9 4 × 𝐶 3 + 1 . 6 8 8 × 𝐶 4 0.878
63, 6 A U C 0 - 1 2 h = 1 . 3 0 5 + 3 . 5 3 4 × 𝐶 3 + 3 . 1 9 9 × 𝐶 6 0.884
70, 2, 6 A U C 0 - 1 2 h = 0 . 2 9 1 + 3 . 9 7 2 × 𝐶 0 + 2 . 3 3 6 × 𝐶 2 + 5 . 4 4 × 𝐶 6 0.879
80, 4, 6 A U C 0 - 1 2 h = 0 . 7 6 8 + 6 . 4 1 2 × 𝐶 0 + 2 . 1 7 2 × 𝐶 4 + 4 . 1 5 2 × 𝐶 6 0.80
91, 2, 4 A U C 0 - 1 2 h = 0 . 7 3 5 + 0 . 3 8 8 × 𝐶 1 + 2 . 3 5 7 × 𝐶 2 + 3 . 6 5 4 × 𝐶 4 0.939
101.5, 3, 4 A U C 0 - 1 2 h = 0 . 7 0 1 + 1 . 9 2 4 × 𝐶 1 . 5 + 2 . 5 4 5 × 𝐶 3 + 1 . 6 8 2 × 𝐶 4 0.921
111.5, 2, 4 A U C 0 - 1 2 h = 0 . 7 3 3 + 2 . 8 3 3 × 𝐶 1 . 5 + 0 . 2 5 2 × 𝐶 2 + 3 . 8 1 8 × 𝐶 4 0.901
120.5, 2, 4 A U C 0 - 1 2 h = 0 . 6 0 7 + 1 . 5 6 9 × 𝐶 0 . 5 + 2 . 0 9 8 × 𝐶 2 + 3 . 6 0 3 × 𝐶 4 0.943
130, 2, 4 A U C 0 - 1 2 h = 0 . 4 6 4 + 5 . 3 8 8 × 𝐶 0 + 2 . 1 5 5 × 𝐶 2 + 2 . 7 0 8 × 𝐶 4 0.909
142, 4, 6 A U C 0 - 1 2 h = 0 . 4 7 1 + 2 . 5 1 × 𝐶 2 + 1 . 3 6 7 × 𝐶 4 + 5 . 0 1 5 × 𝐶 6 0.939
152, 3, 4 A U C 0 - 1 2 h = 0 . 8 0 7 + 1 . 9 5 2 × 𝐶 2 + 2 . 4 9 5 × 𝐶 3 + 1 . 5 0 4 × 𝐶 4 0.925
161, 1.5, 2, 4 A U C 0 - 1 2 h = 0 . 8 4 2 − 0 . 3 7 2 × 𝐶 1 + 2 . 8 3 4 × 𝐶 1 . 5 + 0 . 0 3 6 × 𝐶 2 + 3 . 6 8 1 × 𝐶 4 0.885
172, 4, 6, 8 A U C 0 - 1 2 h = 0 . 1 4 8 + 2 . 4 5 7 × 𝐶 2 + 1 . 5 8 2 × 𝐶 4 + 1 . 2 9 6 × 𝐶 6 + 5 . 8 1 × 𝐶 8 0.965
181, 2, 4, 6 A U C 0 - 1 2 h = 0 . 2 3 + 0 . 8 5 1 × 𝐶 1 + 1 . 5 7 3 × 𝐶 2 + 1 . 5 7 × 𝐶 4 + 5 . 8 3 8 × 𝐶 6 0.954
190, 2, 4, 6 A U C 0 - 1 2 h = 0 . 2 8 7 + 3 . 8 2 1 × 𝐶 0 + 2 . 1 2 7 × 𝐶 2 + 1 . 2 7 1 × 𝐶 4 + 4 . 0 3 3 × 𝐶 6 0.924
201.5, 2, 3, 4 A U C 0 - 1 2 h = 0 . 7 5 + 2 . 7 2 6 × 𝐶 1 . 5 − 1 . 1 3 8 × 𝐶 2 + 2 . 7 6 4 × 𝐶 3 + 1 . 7 8 7 × 𝐶 4 0.909
210.5, 1.5, 2, 4 A U C 0 - 1 2 h = 0 . 7 3 1 + 0 . 3 6 5 × 𝐶 0 . 5 + 1 . 8 9 5 × 𝐶 1 . 5 + 0 . 5 2 4 × 𝐶 2 + 3 . 7 9 3 × 𝐶 4 0.915
220, 1.5, 2, 4 A U C 0 - 1 2 h = 0 . 4 8 3 + 4 . 6 0 4 × 𝐶 0 + 1 . 6 1 3 × 𝐶 1 . 5 + 0 . 4 6 7 × 𝐶 2 + 3 . 0 9 9 × 𝐶 4 0.899
231.5, 2, 4, 6 A U C 0 - 1 2 h = 0 . 4 1 4 + 2 . 4 0 1 × 𝐶 1 . 5 − 0 . 1 4 1 × 𝐶 2 − 1 . 7 4 8 × 𝐶 4 + 5 . 1 3 7 × 𝐶 6 0.934
24Full hours A U C 0 - 1 2 h = 0 . 1 5 2 − 2 . 2 4 9 × 𝐶 0 + 0 . 5 7 7 × 𝐶 0 . 5 + 0 . 8 7 1 × 𝐶 1 − 0 . 0 0 1 × 𝐶 1 . 5 + 0 . 9 6 3 × 𝐶 2 + 1 . 1 6 × 𝐶 3 + 0 . 1 5 2 × 𝐶 4 + 1 . 6 6 × 𝐶 6 + 3 . 4 7 × 𝐶 8 + 2 . 7 0 3 × 𝐶 1 2  0.991