Estimation of Abbreviated Cyclosporine A Area under the Concentration-Time Curve in Allogenic Stem Cell Transplantation after Oral Administration

Table 5

Prediction bias and precision of models for estimating the cyclosporine (CsA) AUC_0–12 h (𝑛=30).

Models	Sampling time (h)	Bias (me%)	Precision (rmse%)
1	2, 4	2.68	11.02
2	0, 2	−0.09	11.74
3	2, 6	5.48	13.63
4	2, 3	4.10	13.08
5	3, 4	0.97	13.97
6	3, 6	2.64	13.28
7	0, 2, 6	−0.60	10.64
8	0, 4, 6	−4.95	15.76
9	1, 2, 4	1.35	9.76
10	1.5, 3, 4	1.30	11.65
11	1.5, 2, 4	0.69	13.57
12	0.5, 2, 4	1.27	9.60
13	0, 2, 4	−2.42	9.54
14	2, 4, 6	2.83	9.61
15	2, 3, 4	2.22	11.33
16	1, 1.5, 2, 4	0.58	15.05
17	2, 4, 6, 8	−0.21	8.04
18	1, 2, 4, 6	2.59	8.50
19	0, 2, 4, 6	−0.60	8.77
20	1.5, 2, 3, 4	41.77	45.19
21	0.5, 1.5, 2, 4	2.39	12.55
22	0, 1.5, 2, 4	−1.25	10.07
23	1.5, 2, 4, 6	3.6	10.78
24	All	2.41	2.86
Mean; IC 95%		2.86 (−0.57–6.29)	12.49 (9.51–15.48)