Urinary NGAL Ratio Is Not a Sensitive Biomarker for Monitoring Acute Tubular Injury in Kidney Transplant Patients: NGAL and ATI in Renal Transplant Patients

Table 2

Urinary NGAL levels (NGAL/creatinine; (ng/g)), and associations with various clinical, laboratory and demographic variables. Results are separately reported for the 6-week and 6-month samples. The remaining variables which were tested without significant differences are reported in the Supplementary Materials.

	6 weeks		𝑃 value	6 months		𝑃 value
	Male	Female		Male	Female
Donor gender	18,875; (𝑛=47)	23,910; (𝑛=37)	0.31	12,264; (𝑛=35)	21,785; (𝑛=37)	0.071
Recipient gender	18,242; (𝑛=54)	37,855; (𝑛=30)	0.011	11,491; (𝑛=44)	32,613; (𝑛=28)	0.000
GFR^a	𝑅=−0.204		0.066	𝑅=−0.321		0.006
	6 weeks		𝑃 value	6 months		𝑃 value
	Not present	Present		Not present	Present
Delayed graft function	18,875 (𝑛=13)	21,315; (𝑛=71)	0.218	17,554; (𝑛=45)	19,354; (𝑛=27)	0.866
Isometric vacuolization^b	19,187 (𝑛=61)	31,224; (𝑛=23)	0.031	22,436; (𝑛=47)	9,480; (𝑛=25)	0.008
cGrade >0^b	19,031 (𝑛=70)	39,575; (𝑛=14)	0.033	14,218; (𝑛=44)	21,115; (𝑛=28)	0.583
Urinary tract infection at the time of sampling	17,901 (𝑛=63)	50,548; (𝑛=14)	0.000	13,760; (𝑛=56)	64,889; (𝑛=6)	0.014
Panel reactive antibodies at transplantation > 0%	22,952; (𝑛=76)	11,696; (𝑛=7)	0.019	17,194; (𝑛=66)	33,929; (𝑛=6)	0.342
Blood transfusion before transplantation	19,530; (𝑛=57)	25,876; (𝑛=18)	0.449	13,286; (𝑛=47)	30,322; (𝑛=18)	0.022
MMF in the initial immunosuppression	27,842; (𝑛=31)	19,187; (𝑛=53)	0.245	24,208; (𝑛=32)	17,875; (𝑛=40)	0.019
Coronary heart disease before transplantation	16,502; (𝑛=70)	21,822; (𝑛=14)	0.116	19,354; (𝑛=61)	8,969; (𝑛=11)	0.043

^aGFR calculated according to the Cockroft and Gault formula at the time of sampling, ^baccording to the BANFF classification, at the time of sampling.