The Major Histocompatibility Complex in Transplantation

Figure 2

Allogeneic immune response: this could happen by three recognizing mechanisms: first, an indirect recognition: this type of mechanism has a dominant role in chronic rejection; second, a direct recognition: this mechanism determines a strong immune response in the acute rejection; third mechanism, a “semi-direct” recognition that could be mediated by immunoglobulin-like receptors of natural killer (NK) cells and can mediate potent acute rejection.