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Journal of Transplantation
Volume 2012, Article ID 896141, 9 pages
http://dx.doi.org/10.1155/2012/896141
Research Article

Immunosuppressive Activity of Size-Controlled PEG-PLGA Nanoparticles Containing Encapsulated Cyclosporine A

1Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
2Transplantation Research Center, Renal Division, Brigham and Women's Hospital; Children's Hospital Boston, Harvard Medical School, Boston, MA 02139, USA
3Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA

Received 13 October 2011; Accepted 6 December 2011

Academic Editor: Andreas Zuckermann

Copyright © 2012 Li Tang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. D. Kahan, “Drug therapy: cyclosporine,” New England Journal of Medicine, vol. 321, no. 25, pp. 1725–1738, 1989. View at Google Scholar · View at Scopus
  2. T. E. Starzl, G. B. G. Klintmalm, and R. Weil III, “Cyclosporin A and steroid therapy in sixty-six cadaver kidney recipients,” Surgery Gynecology and Obstetrics, vol. 153, no. 4, pp. 486–494, 1981. View at Google Scholar · View at Scopus
  3. D. Faulds, K. L. Goa, and P. Benfield, “Cyclosporin: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders,” Drugs, vol. 45, no. 6, pp. 953–1040, 1993. View at Google Scholar · View at Scopus
  4. J. L. Italia, V. Bhardwaj, and M. N. V. Ravi Kumar, “Disease, destination, dose and delivery aspects of ciclosporin: the state of the art,” Drug Discovery Today, vol. 11, no. 17-18, pp. 846–854, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. S. M. Moghimi, A. C. Hunter, and J. C. Murray, “Nanomedicine: current status and future prospects,” FASEB Journal, vol. 19, no. 3, pp. 311–330, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. P. R. Beauchesne, N. S. C. Chung, and K. M. Wasan, “Cyclosporine A: a review of current oral and intravenous delivery systems,” Drug Development and Industrial Pharmacy, vol. 33, no. 3, pp. 211–220, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Czogalla, “Oral cyclosporine A—the current picture of its liposomal and other delivery systems,” Cellular and Molecular Biology Letters, vol. 14, no. 1, pp. 139–152, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. D. D. Ankola, A. Battisti, R. Solaro, and M. N. V. R. Kumar, “Nanoparticles made of multi-block copolymer of lactic acid and ethylene glycol containing periodic side-chain carboxyl groups for oral delivery of cyclosporine A,” Journal of the Royal Society Interface, vol. 7, no. 4, pp. S475–S481, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Gref, P. Quellec, A. Sanchez, P. Calvo, E. Dellacherie, and M. J. Alonso, “Development and characterization of CyA-loaded poly(lactic acid)-poly(ethylene glycol)PEG micro- and nanoparticles. Comparison with conventional PLA particulate carriers,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 51, no. 2, pp. 111–118, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. J. L. Italia, D. K. Bhatt, V. Bhardwaj, K. Tikoo, and M. N. V. R. Kumar, “PLGA nanoparticles for oral delivery of cyclosporine: nephrotoxicity and pharmacokinetic studies in comparison to Sandimmune Neoral®,” Journal of Controlled Release, vol. 119, no. 2, pp. 197–206, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Zhang, X. Li, Y. Zhou et al., “Preparation and evaluation of poly(ethylene glycol)-poly(lactide) micelles as nanocarriers for oral delivery of Cyclosporine A,” Nanoscale Research Letters, vol. 5, no. 6, pp. 917–925, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Azzi, L. Tang, R. Moore et al., “Polylactide-cyclosporin A nanoparticles for targeted immunosuppression,” FASEB Journal, vol. 24, no. 10, pp. 3927–3938, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. D. Grant, N. Kneteman, J. Tchervenkov et al., “Peak cyclosporine levels (C(max)) correlate with freedom from liver graft rejection: results of a prospective, randomized comparison of Neoral and Sandimmune for liver transplantation (NOF-8),” Transplantation, vol. 67, no. 8, pp. 1133–1137, 1999. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Ho, N. Clipstone, L. Timmermann et al., “The mechanism of action of cyclosporin A and FK506,” Clinical Immunology and Immunopathology, vol. 80, no. 3, pp. S40–S45, 1996. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Wang, S. Wang, H. Su et al., “A supramolecular approach for preparation of size-controlled nanoparticles,” Angewandte Chemie, vol. 48, no. 24, pp. 4344–4348, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. S. T. Reddy, A. J. Van Der Vlies, E. Simeoni et al., “Exploiting lymphatic transport and complement activation in nanoparticle vaccines,” Nature Biotechnology, vol. 25, no. 10, pp. 1159–1164, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Cheng, B. A. Teply, I. Sherifi et al., “Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery,” Biomaterials, vol. 28, no. 5, pp. 869–876, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Izawa, T. Ueno, M. Jurewicz et al., “Importance of donor- and recipient-derived selectins in cardiac allograft rejection,” Journal of the American Society of Nephrology, vol. 18, no. 11, pp. 2929–2936, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. P. Fiorina, M. Jurewicz, A. Vergani et al., “Phenotypic and functional differences between wild-type and CCR2 -/- dendritic cells: implications for islet transplantation,” Transplantation, vol. 85, no. 7, pp. 1030–1038, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Galindo-Rodriguez, E. Allémann, H. Fessi, and E. Doelker, “Physicochemical parameters associated with nanoparticle formation in the salting-out, emulsification-diffusion, and nanoprecipitation methods,” Pharmaceutical Research, vol. 21, no. 8, pp. 1428–1439, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. R. Tong and J. Cheng, “Controlled synthesis of camptothecin-polylactide conjugates and nanoconjugates,” Bioconjugate Chemistry, vol. 21, no. 1, pp. 111–121, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. P. Caliceti and F. M. Veronese, “Pharmacokinetic and biodistribution properties of poly(ethylene glycol)-protein conjugates,” Advanced Drug Delivery Reviews, vol. 55, no. 10, pp. 1261–1277, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. O. C. Farokhzad, J. Cheng, B. A. Teply et al., “Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 16, pp. 6315–6320, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Tong, L. Yala, T. M. Fan, and J. Cheng, “The formulation of aptamer-coated paclitaxel-polylactide nanoconjugates and their targeting to cancer cells,” Biomaterials, vol. 31, no. 11, pp. 3043–3053, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Sakuma, Y. Kato, F. Nishigaki et al., “Effects of FK506 and other immunosuppressive anti-rheumatic agents on T cell activation mediated IL-6 and IgM production in vitro,” International Immunopharmacology, vol. 1, no. 4, pp. 749–757, 2001. View at Publisher · View at Google Scholar · View at Scopus
  26. R. Abdi, R. Neal Smith, L. Makhlouf et al., “The role of CC chemokine receptor 5 (CCR5) in islet allograft rejection,” Diabetes, vol. 51, no. 8, pp. 2489–2495, 2002. View at Google Scholar · View at Scopus
  27. X. Yuan, J. Paez-Cortez, I. Schmitt-Knosalla et al., “A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy,” Journal of Experimental Medicine, vol. 205, no. 13, pp. 3133–3144, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Lohr, B. Knoechel, J. W. Jing, A. V. Villarino, and A. K. Abbas, “Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease,” Journal of Experimental Medicine, vol. 203, no. 13, pp. 2785–2791, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. W. Jiang, B. Y. S. Kim, J. T. Rutka, and W. C. W. Chan, “Nanoparticle-mediated cellular response is size-dependent,” Nature Nanotechnology, vol. 3, no. 3, pp. 145–150, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. M. E. Fox, F. C. Szoka, and J. M. J. Fréchet, “Soluble polymer carriers for the treatment of cancer: the importance of molecular architecture,” Accounts of Chemical Research, vol. 42, no. 8, pp. 1141–1151, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. F. Alexis, E. Pridgen, L. K. Molnar, and O. C. Farokhzad, “Factors affecting the clearance and biodistribution of polymeric nanoparticles,” Molecular Pharmaceutics, vol. 5, no. 4, pp. 505–515, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. U. Bilati, E. Allémann, and E. Doelker, “Development of a nanoprecipitation method intended for the entrapment of hydrophilic drugs into nanoparticles,” European Journal of Pharmaceutical Sciences, vol. 24, no. 1, pp. 67–75, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. V. Y. Senichev and V. V. Tereshatov, “General principles governing dissolution of materials in solvents: simple solvent characteristics,” ChemInform, vol. 34, no. 8, pp. 101–242, 2003. View at Google Scholar
  34. R. Singh and J. W. Lillard Jr., “Nanoparticle-based targeted drug delivery,” Experimental and Molecular Pathology, vol. 86, no. 3, pp. 215–223, 2009. View at Publisher · View at Google Scholar · View at Scopus