Clinical Study

Low CD4/CD8 Ratio in Bronchus-Associated Lymphoid Tissue Is Associated with Lung Allograft Rejection

Table 4

Summary of recent BALT literature.

AuthorDisease stateBALT conclusion

Hogg et al., 2004 [2]COPDIncreased BALT presence with worsening disease severity
Rangel-Moreno et al., 2006 [3]Rheumatoid lungInduced BALT presence correlates with increased lung tissue damage
Prop et al., 1985 [4]Animal lung transplantPresence of BALT correlates with rejection. Removal of BALT through irradiation of donor abrogates rejection
Hasegawa et al., 1999 [5]Human lung transplantBALT presence correlates with minimal to no rejection. BALT may play role in immune tolerance