Low CD4/CD8 Ratio in Bronchus-Associated Lymphoid Tissue Is Associated with Lung Allograft Rejection
Summary of recent BALT literature.
|Author||Disease state||BALT conclusion|
|Hogg et al., 2004 ||COPD||Increased BALT presence with worsening disease severity|
|Rangel-Moreno et al., 2006 ||Rheumatoid lung||Induced BALT presence correlates with increased lung tissue damage|
|Prop et al., 1985 ||Animal lung transplant||Presence of BALT correlates with rejection. Removal of BALT through irradiation of donor abrogates rejection|
|Hasegawa et al., 1999 ||Human lung transplant||BALT presence correlates with minimal to no rejection. BALT may play role in immune tolerance|