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Journal of Transplantation
Volume 2013 (2013), Article ID 614610, 8 pages
http://dx.doi.org/10.1155/2013/614610
Review Article

Outcome and Challenges of Kidney Transplant in Patients with Sickle Cell Disease

Renal Unit, Department of Medicine, Enugu State University Teaching Hospital Parklane, Enugu, Nigeria

Received 15 December 2012; Revised 28 February 2013; Accepted 12 March 2013

Academic Editor: Parmjeet Randhawa

Copyright © 2013 U. H. Okafor and E. Aneke. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Sickle cell nephropathy is a common presentation in patients with sickle cell disease. End-stage kidney disease is the most severe presentation of sickle cell nephropathy in terms of morbidity and mortality. Sickle cell disease patients with end-stage kidney disease are amenable to renal replacement therapy including kidney transplant. Kidney transplant in these patients has been associated with variable outcome with recent studies reporting short- and long-term outcomes comparable to that of patients with HbAA. Sickle cell disease patients are predisposed to various haematological, cardiorespiratory, and immunological challenges. These challenges have the potential to limit, delay, or prevent kidney transplant in patients with sickle cell disease. There are few reports on the outcome and challenges of kidney transplant in this group of patients. The aim of this review is to highlight the outcome and challenges of kidney transplant in patients with sickle cell disease.