Neutrophil Gelatinase-Associated Lipocalin in Kidney Transplantation Is an Early Marker of Graft Dysfunction and Is Associated with One-Year Renal Function

Table 5

Area under the receiver-operating characteristic curve at each time point for uNGAL, serum creatinine, and serum cystatin C for predicting DGF.

	Time after transplant	AUC (95% CI)	𝑃 value
Urine NGAL (ng/mL)	Shortly after surgery (3 to 6 h)	0.77 (0.58–0.97)	0.010
	1st day (8 to 12 h after surgery)	0.88 (0.77–1.0)	<0.001
	2nd day	0.96 (0.90–1.0)	<0.001
	4th day	0.99 (0.97–1.0)	<0.001
	7th day	0.93 (0.86–1.0)	<0.001
Serum creatinine (mg/dL)	Prior transplantation	0.56 (0.38–0.74)	0.514
	1st day (8 to 12 h after surgery)	0.77 (0.61–0.93)	0.007
	2nd day	0.90 (0.79–1.0)	<0.001
	4th day	0.95 (0.87–1.0)	<0.001
	7th day	0.93 (0.81–1.0)	<0.001
Serum cystatin C (mg/L)	1st day (6 to 12 h after surgery)	0.90 (0.79–1.0)	<0.001
	2nd day	0.96 (0.88–1.0)	<0.001
	4th day	0.95 (0.89–1.0)	<0.001
	7th day	0.93 (0.83–1.0)	<0.001

DGF: delayed graft function; uNGAL: urinary neutrophil gelatinase-associated lipocalin.