Current Practice of Heart Donor Evaluation in Germany: Multivariable Risk Factor Analysis Confirms Practicability of Guidelines
Table 2
Multivariate logistic regression models comparing Level A versus C and Level B versus C.
Variable
Level A versus C (: A = 1165; C = 1009)
Level B versus C (: B = 447; C = 1009)
OR
95% CI
value
OR
95% CI
value
Age per year
0.87
0.85
0.89
<0.0001
0.95
0.94
0.96
<0.0001
Height per cm
1.04
1.02
1.06
<0.0001
1.02
1.02
1.03
<0.0001
ICU stay (per day)
1.40
1.21
1.61
<0.0001
Cause of death (brain damage) secondary versus traumatic
0.21
0.09
0.50
0.0004
Electrocardiogram: severe changes versus normal
0.05
0.01
0.26
0.0004
0.25
0.08
0.76
0.0150
Echocardiography left ventricular hypertrophy: severe (IVSd > 16 mm) versus none
0.20
0.09
0.49
0.0004
0.43
0.21
0.85
0.0154
Echocardiography left ventricular function: severely reduced (LVEF < 40%) versus good (LVEF ≥ 50%)
0.01
0.002
0.04
<0.0001
0.08
0.02
0.36
0.0008
Echocardiography heart valves: stenosis or insufficiency >1° versus normal
0.04
0.01
0.11
<0.0001
0.32
0.14
0.73
0.0072
Echocardiography wall motion abnormality: severe hypokinesia versus none
0.03
0.01
0.10
<0.0001
0.24
0.11
0.52
0.0003
Echocardiography wall motion abnormality: segmental akinesia versus none
0.03
0.004
0.21
0.0004
0.39
0.09
1.71
0.2116
History of arterial hypertension
0.36
0.20
0.63
0.0003
Pneumonia
0.56
0.34
0.92
0.0213
Hepatitis B
0.33
0.19
0.57
<0.0001
Hepatitis C
0.11
0.02
0.53
0.0060
0.07
0.03
0.15
<0.0001
Norepinephrine (most recent) >0.2 versus 0 µg/kg/min
0.40
0.20
0.79
0.0091
Blood transfusions
0.52
0.27
0.99
0.0448
CK (creatine kinase) per 100 IU/L
0.99
0.99
0.10
0.0256
Troponin T or I: >0.2 versus <0.1 ng/mL
0.19
0.07
0.54
0.0018
0.27
0.14
0.51
<0.0001
LDH (lactate dehydrogenase) per 10 IU/L
0.98
0.98
0.99
0.0001
Coronary artery disease known before donor evaluation
0.003
<0.001
0.01
<0.0001
0.03
0.01
0.09
<0.0001
Coronary angiography (if indicated) not performed versus normal
0.06
0.03
0.15
<0.0001
0.40
0.27
0.60
<0.0001
Blank lines indicate that the parameter was not relevant in the particular model. OR describes probability of heart transplantation when a risk factor exists compared to reference. There was a high concordance between study group and validation group. Therefore only data from study group data are shown here. IVSd: interventricular septal thickness at diastole; LVEF: left ventricular ejection fraction.
