Should We Consider Patients with Coexistent Hepatitis B or C Infection for Orthotopic Heart Transplantation?

Table 2

Studies correlating HBV/HCV infection and clinical outcomes in other solid organ transplantation processes.

Author	Country	Transplanted organ	Cohort size	Follow-up	Measure	Outcome
Roth et al., 2011 [15]	USA	Kidney	𝑛=110	10 years	Long-term outcome of RTx in HCV+ patients	RTx confers a long-term survival benefit
Knoll et al., 1997 [16]	USA	Kidney	𝑛 = 2053; HCV+ 𝑛=151; RTx 𝑛=33; Waiting list 𝑛=25	2 years	Outcomes in HCV+ RTx recipients to HCV+ ESRD patients	Decreased survival in HCV+ patients on waiting list compared to those who had RTx
Fabrizi et al., 2005 [17]	Italy	Kidney	𝑛=6050		Outcome of RTx in HBV+ patients	Increased mortality in HBV+ recipients than HBV− recipients
Reddy et al., 2011 [18]	USA	Kidney	𝑛 = 75,861; HBV+ 𝑛=1346; HBV−  𝑛 = 74,335	5 years	Patient/graft survival in HBV+ recipients	Patient/graft survival in HBV+ was comparable to HBV− recipients
Sahi et al., 2007 [19]	USA	Lung	𝑛=465; HCV+ 𝑛=6	3.2 years	Outcome of lung transplant in HCV+ recipients compared to HCV− controls	No significant difference in patient and graft survival
Hartwig et al., 2005 [20]	USA	Lung	𝑛=456; HB group 𝑛=29; HC group 𝑛=3		Outcome of the use of HbcAb+ and HCVAb+ allografts	Use of HbcAb+ allografts in recipients with prior immunisation was safe
Dhillon et al., 2009 [21]	USA	Heart-lung	HbcAb+ 𝑛=333; HbcAb−  𝑛 = 13,233	5 years	Impact of donor HbcAb+ status on outcomes of lung and heart-lung recipients	Lungs and heart-lung allografts from HbcAb+ donors may be safely used
Singal et al., 2013 [22]	USA	Liver	𝑛 = 54687	5 years	Outcomes of liver transplant based on etiology of liver disease	Worst outcome in HCV+, HCV+, and alcohol
Reddy and Everson 2013 [23]	USA	Liver	𝑛=1	60 weeks	Treatment of HCV recurrence with protease inhibitor based therapy	Intervention with protease based therapy is justified in HCV eradication

HBV: hepatitis B virus, ESRD: end-stage renal disease, HbcAb: hepatitis B core antibody, HCV: hepatitis C virus, RTX: renal transplantation, HCV Ab: hepatitis C antibody.