Preconditioning Serum Levels of Endothelial Cell-Derived Molecules and the Risk of Posttransplant Complications in Patients Treated with Allogeneic Stem Cell Transplantation

Table 2

Unsupervised hierarchical clustering of serum soluble adhesion levels for 50 unselected patients treated with allogeneic stem cell transplantation; a comparison of the two main patient subsets including the 23 patients to the right and the 27 patients to the left in Figure 2, respectively.

Adhesion molecule—clinical parameter	Left patient subset,	Right patient subset,	value
Endocan (ng/mL)	1.567 (0.908–2.452)	0.893 (0.148–2.901)	0.0516
VCAM-1 (ng/mL)	691.6 (317.3–1130.0)	1410 (300.0–5816.4)	0.0048
E-selectin (ng/mL)	25.4 (9.0–54.8)	21.7 (12.9–104.1)	0.4595
Frequency of early nonrelapse death	2/27	8/23	0.007
Time to neutrophils ≥0.2 × 10^9/L	14.5 days (11–19 days)	15 days (10–26 days)	ns
Time to neutrophils >0.5 × 0^9/L	16 days (11–24 days)	18 days (12–28 days)	0.052
Time to platelets >20 × 10^9/L	12 days (9–>22 days)	16 days (12–30 days)	0.032
Time to platelets >50 × 10^9/L	16 days (12–38 days)	25 days (13–>71 days)	0.028

The Mann-Whitney test was used for statistical analyses. Results are presented as the median value and the variation range. Patients who died before reaching platelet reconstitution were not included in the statistical comparison of time until reconstitution (ns: not significant).