Proximal Tubular Injury in Medullary Rays Is an Early Sign of Acute Tacrolimus Nephrotoxicity

Table 2

KIM-1 score, renal functional indices, and tacrolimus levels in three groups of renal transplant biopsies.

	Three groups	KIM-1 scores	Serum Cr (mg/dL)	Serum tacrolimus (ng/dL)
Group 1	Controls (KIM-1 negative)	0.00 ± 0.00	1.24 ± 0.09	8.53 ± 0.76
Group 2	KIM-1 + in all cortical PT	1.86 ± 0.16	4.20 ± 0.49	5.92 ± 0.61
Group 3	KIM-1 + in PT of medullary rays	1.16 ± 0.10	1.89 ± 0.26^#	10.85 ± 0.60

versus group 1, ^# versus group 2; PT: proximal tubules.