Delayed Graft Function in Kidney Transplants: Time Evolution, Role of Acute Rejection, Risk Factors, and Impact on Patient and Graft Outcome
Table 1
Time evolution of demographic characteristics in 1784 transplantations performed from 1983 to 2014.
Transplant years
1983–1991
1992–1997
1998–2003
2004–2009
2010–2014
value
Number of missing values
Number of grafts
421
385
346
353
279
<1998
1998
Recipient
Male gender
60.8
61.8
61.9
62.9
62.0
0.99
Age (y)
35.8 ± 9.7
39.1 ± 11.1
46.7 ± 12.4
50.6 ± 12.4
53.1 ± 12.8
<0.001
Regrafting
20.2
17.1
26.3
13.6
15.1
<0.001
Duration of regular dialysis (y)
3.5 ± 3.0
3.7 ± 3.0
4.1 ± 4.6
3.1 ± 2.9
3.5 ± 3.1
0.007
History of diabetes
1.1
0
4.0
11.9
15.1
<0.001
History of cardiovascular disease
4.8
6.5
10.4
22.4
13.6
<0.001
Peak (>50% PRA) sensitization
20.7
6.8
9.2
8.2
6.1
<0.001
Delayed graft function (DGF)
48.7
17.7
16.5
11.0
4.7
<0.001
Perioperative saline loading
0
100
100
100
100
<0.001
Use of mycophenolate mofetil
0
4.9
83.5
92.1
98.9
<0.001
Immunoglobulin induction
56.5
95.3
78.6
92.9
98.9
<0.001
ARE occurring during DGF period
27.3
10.7
5.8
6.3
3.6
<0.001
Biopsy proven
79.8
90.4
94.2
94.6
96.8
<0.001
Residual diuresis (<500 mL/24 h)
69.0
66.5
64.5
51.3
52.3
<0.001
267
127
BMI (kg/m2)
22.7 ± 3.8
23.9 ± 3.6
24.5 ± 4.3
25.2 ± 4.7
25.3 ± 4.8
<0.001
271
126
Donor
Male gender
60.9
62.2
59.5
58.4
50.5
0.024
Age (y)
52.4 ± 14.3
37.5 ± 14.4
42.7 ± 16.0
44.0 ± 15.1
48.8 ± 13.0
<0.001
Donation after cardiac death
0
0
1.2
2.7
13.6
<0.001
Traumatic cause of death
57.9
45.7
40.8
34.9
27.2
<0.001
11
8
Terminal serum creatinine (mg/dL)
1.00 ± 0.39
0.95 ± 0.36
0.91 ± 0.33
0.77 ± 0.31
0.70 ± 0.25
<0.001
43
51
BMI (kg/m2)
23.2 ± 4.0
23.7 ± 3.5
24.7 ± 4.2
24.9 ± 4.6
25.6 ± 4.3
<0.001
132
131
Transplant
Ischaemia times
Cold (h)
27.3 ± 7.6
22.8 ± 6.2
18.8 ± 6.0
17.2 ± 5.0
16.3 ± 5.5
<0.001
0
2
Warm (min)
34.2 ± 7.9
33.0 ± 7.8
33.2 ± 8.3
30.0 ± 7.5
32.6 ± 9.0
<0.001
0
2
Number of HLA-A+B+DR mismatches
2.6 ± 1.5
2.2 ± 1.3
2.7 ± 1.3
2.5 ± 1.2
2.6 ± 1.1
<0.001
Nominal variables are expressed as percent of total grafts and numerical variables as mean ± standard deviation.
PRA: panel reactive antibodies; ARE: acute rejection episode; BMI: body mass index.
