MicroRNAs in Kidney Transplantation: Living up to Their Expectations?

Table 2

Overview of experiments using human (kidney) tissue. LTx = liver transplantation. IF/TA = interstitial fibrosis and tubular atrophy. STA = soluble transplant antigen. AMR = antibody-mediated rejection. DGF = delayed graft function.

Author	Group	Focus	Control	Tissue	Time point after transplantation	MicroRNA−	MicroRNA+
Sui et al. [9],; 2008	Human live kidney donors	Acute rejection	Tumor nephrectomy	Cortex	Histologically confirmed acute rejection	miR-17-3p MM1; miR-197 MM2; miR-326; miR-330 MM1; miR-346; miR-483; miR-516; miR-524*; miR-611; miR-654; miR-663	miR-125a MM1; miR-125a; miR-320; miR-381; miR-602; miR-628; miR-629; miR-658
Anglicheau et al. [10], 2009	Human living + deceased donors	Acute rejection	Normal allograft	Biopsy	Variable	Let-7c; miR-10a; miR-10b; miR-30a; miR-30b; miR-30c; miR-30e-3p; miR-32; miR-125a; miR-200a	miR-142-3p; miR-142-5p; miR-146a; miR-146b; miR-155; miR-223; miR-342
Lorenzen et al. [11],; 2011	Human living + deceased donors	Acute rejection	Normal allograft/urinary tract infection	Biopsy, urine	6 weeks; 3 months; 6 months	miR-10b; miR-210	miR-10a
Scian et al. [13],; 2011	Human deceased donors	IF/TA	Normal allograft	Biopsy, urine	>9 months	miR-107; miR-204; miR-211	miR-32; miR-142-3p
Ben-Dov et al. [12],; 2012	Human living + deceased donors	IF/TA	Normal allograft	Biopsy, urine	Variable	miR-30 family	miR-21; miR-21*; miR-142-3p; miR-223; miR-506; miR-508; miR-509-3p; miR-509-5p; miR-514a
Danger et al. [15],; 2012	Human living + deceased donors	STA	Operationally tolerant/healthy volunteers/LTx recipient	PBMCs	Variable	miR-106b; miR-142-3p; miR-450b-3p; miR-876-3p	miR-98; miR-148b; miR-324-5p; miR-508-3p
Danger et al. [32], 2013	Human PBMC	Chronic; AMR	Acute rejection/healthy volunteers/renal failure	PBMCs	Variable		miR-142-5p
Wilflingseder et al. [14],; 2013	Human living + decreased donors	AMR	Normal allograft	Biopsy	Variable		Let-7i; miR-21*; miR-146b-5p; miR-182; miR-663; miR-1228
		Acute rejection				Let-7b; miR-23b; miR-27b; miR-30c-2*; miR-99b; miR-99b*; miR-125a; miR-125b-2*; miR-138; miR-139-5p; miR-181a; miR-181b; miR-193b; miR-361-5p; miR-424*; miR-455; miR-502-3p; miR-574-3p	miR-150; miR-155; miR-663a; miR-638
		DGF					miR-17; miR-18a; miR-20a; miR-21*; miR-106a; miR-106b; miR-182
Maluf [34],; 2014	Human; deceased donors	IF/TA	Normal allograft	Urine	Variable	miR-23b; miR-30a; miR-99a; miR-125b; miR-184; miR-193b; miR-200b; miR-203; miR-375; miR-513a-5p; miR-575	Let-7f-2; miR-92a; miR-106b; miR-140a-3p; miR-185; miR-345; miR-423-5p; miR-425; miR-451; miR-486-5p