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Journal of Transplantation
Volume 2015, Article ID 949674, 8 pages
http://dx.doi.org/10.1155/2015/949674
Research Article

Risk Factors Associated with Increased Morbidity in Living Liver Donation

1Hepatology and Liver Transplantation, Hospital Sírio-Libanês, Rua Barata Ribeiro 414, cj 65, 01308-000 Bela Vista, SP, Brazil
2Hepatology and Liver Transplantation, A.C. Camargo Cancer Center, São Paulo, SP, Brazil
3Department of Anesthesiology, Hospital Sírio-Libanês, Rua Barata Ribeiro 414, cj 65, 01308-000 Bela Vista, SP, Brazil
4Department of Anesthesiology, A.C. Camargo Cancer Center, São Paulo, Brazil
5Department of Anesthesiology and Intensive Care Therapy, Pulmonary Engineering Group, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
6Department of Anesthesiology, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain

Received 16 July 2015; Revised 19 November 2015; Accepted 24 November 2015

Academic Editor: Patrizia Burra

Copyright © 2015 Helry L. Candido et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Living donor liver donation (LDLD) is an alternative to cadaveric liver donation. We aimed at identifying risk factors and developing a score for prediction of postoperative complications (POCs) after LDLD in donors. This is a retrospective cohort study in 688 donors between June 1995 and February 2014 at Hospital Sírio-Libanês and A.C. Camargo Cancer Center, in São Paulo, Brazil. Primary outcome was POC graded ≥III according to the Clavien-Dindo classification. Left lateral segment (LLS), left lobe (LL), and right lobe resections (RL) were conducted in 492 (71.4%), 109 (15.8%), and 87 (12.6%) donors, respectively. In total, 43 (6.2%) developed POCs, which were more common after RL than LLS and LL (14/87 (16.1%) versus 23/492 (4.5%) and 6/109 (5.5%), resp., ). Multivariate analysis showed that RL resection (OR: 2.81, 95% CI: 1.32 to 3.01; ), smoking status (OR: 3.2, 95% CI: 1.35 to 7.56; ), and blood transfusion (OR: 3.15, 95% CI: 1.45 to 6.84; ) were independently associated with POCs. RL resection, intraoperative blood transfusion, and smoking were associated with increased risk for POCs in donors.