C1Q Assay Results in Complement-Dependent Cytotoxicity Crossmatch Negative Renal Transplant Candidates with Donor-Specific Antibodies: High Specificity but Low Sensitivity When Predicting Flow Crossmatch

Table 2

Sensitivity, specificity, PPV, and NPV of DSA C1q+ Ab; C1q+ Ab (DSA and non-DSA); DSA LABScreen SAB MFI > 2,300; and DSA > 2,300 plus C1q+ Ab (DSA and non-DSA).

	DSA C1q+ Ab	C1q+ Ab (DSA & non-DSA)	DSA-MFI > 2300	DSA > 2300 plus C1q+ Ab (DSA & non-DSA)
Sensitivity	36% (15.1–56.8)	76.0 (57.2–94.7)	72.0 (52.4–91.6)	92.0 (79.3–100)
Specificity	95.8% (85.7–100)	70.8 (50.5–91.1)	75.0 (55.5–94.4)	54.1 (32.1–76.1)
PPV	90 (66.4–100)	73.08 (54.1–92.05)	73.47 (55.5–94.4)	67.65 (50.45–84.84)
NPV	58.9 (42.2–75.6)	73.91 (53.7–94.03)	72.0 (52.4–91.6)	86.67 (66.13–100)