Review Article
Immunomodulatory Role of Mesenchymal Stem Cell Therapy in Vascularized Composite Allotransplantation
Table 3
Monitoring of immunomodulation in preclinical in vivo studies.
| | Authors | IL-6 | TGF-β1 | IL-10 | TNF-α | IFN-γ | |
| | Bartholomew et al. (2002) [23] | — | — | — | — | — | — |
| | Aksu et al. (2008) [24] | — | — | — | — | — | — |
| | Sbano et al. (2008) [25] | — | Skin mRNA
MSC only: ND
MSC + CsA: | Skin mRNA
MSC only: ND
MSC + CsA: ND | Skin mRNA
MSC only: ND
MSC + CsA:
| Skin mRNA
MSC only:
MSC + CsA: ND | — |
| | Pan et al. (2010) [26] | — | — | — | — | — | — |
| | Kuo et al. (2009) [27] | — | — | — | — | — | Circulation and skin
MSC + CsA: ↑
MSC only: ND |
| | Kuo et al. (2011) [28] | — | — | — | — | — | Circulation and skin
MSC + CsA: ↑
MSC only: ND |
| | Kuo et al. (2011) [29] | — | Circulation
MSC + CsA: ↑
| Circulation
MSC + CsA: ↑
| — | — | Circulation and skin
MSC + CsA: ↑
|
| | Kuo et al. (2012) [30] | Skin: ↓
| Skin
MSC + CsA: ↑
MSC only: ↑
Circulation: ND | Circulation
MSC + CsA: ↑
MSC only: ↑
| Circulation
MSC + CsA: ↓
MSC only: ↓
| Circulation: ND | Circulation and skin
MSC + CsA: ↑
MSC only: ND |
| | Larocca et al. (2013) [31] | Lymph node: ↑
Skin: ND | Lymph node: ND
Skin: ND | Lymph node: ↑
Skin: ND | — | Lymph node: ↑
Skin: ND | Lymph node: ↑
Skin: ND |
| | Lee et al. (2014) [32] | Circulation
ASC: ↓
CM: ↓
| — | Skin mRNA
ASC: ND
CM: ↓
| Skin mRNA
ASC: ND
CM: ↓
| Skin mRNA
ASC: ND
CM: ↓
| — |
| | Jeong et al. (2014) [33] | — | — | — | — | — | Skin and muscle: ↑
|
| | Cheng et al. (2014) [34] | — | — | — | — | — | Circulation
VCA tolerant: ↑
VCA intolerant: ND |
| | Ramirez et al. (2014) [35] | — | — | — | | | Circulation
VCA tolerant: ↑
VCA intolerant:
ND |
| | Davis et al. (2014) [37] | — | — | — | — | — | Circulation and splenocytes: ↑
|
| | Plock et al. (2015) [36] | — | — | — | — | — | Circulation
ASC: ↑
BMSC: ND |
|
|
ND: not different statistically; ↑: increased; ↓: decrease.
|
