Liver Transplantation for Hepatocellular Carcinoma: A Single Center Resume Overlooking Four Decades of Experience

Figure 8

Cumulative recurrence of HCC (hospital mortality excluded) () (for statistics see Table 3). (a) Underlying disease had no significant impact on HCC recurrence. (b) UICC-7 staging had a significant impact on HCCR. Only UICC I and II staged tumors were comparable to the reference category of no or necrotic tumors, while tumors of UICC-7 IIIA-IVB had significantly higher rates of HCCR. (c) The group of patients transplanted outside the histologic MILAN (hMILAN) had a maximum cumulative HCC recurrence rate of almost 70% at 10.4 years after LT, while patients transplanted inside hMILAN (reference category) only had a maximum cumulative HCC recurrence rate of about 25% at 7 years after LT. (d) Vascular infiltration was a highly significant predictor of HCC recurrence, while tumors without vascular infiltration had a comparable HCC recurrence rate compared to the reference group of no or necrotic tumors. (e) Neoadjuvant therapy had no significant impact on HCC recurrence. (f) Tumor grading was a significant hazard for HCC recurrence. G1 staged tumors had a comparable risk for HCC recurrence to the reference category (no or necrotic tumors), while G2 and G3-4 staged tumors were strong significant hazards for HCC recurrence.

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