Liver Transplantation for Hepatocellular Carcinoma: A Single Center Resume Overlooking Four Decades of Experience

Table 5

Identification of hazards for HCC recurrence by univariate Cox regression, (hospital deaths excluded).

Univariate Cox regressions for HCC recurrence				exp()/hazard	95.0% CI
					Lower	Upper
Underlying disease	Hepatitis B with D	12	0.176	Reference category
	Hepatitis B	64	0.405	1.667	0.5	5.555
	Hepatitis C	75	0.847	1.126	0.336	3.777
	Hepatitis C with B	9	0.419	0.394	0.041	3.784
	Alcohol	33	0.131	2.603	0.752	9.003
	Cryptogenic cirrhosis	38	0.375	1.76	0.505	6.128
	Other	20	0.417	1.732	0.459	6.53
Tumor vitality	Vital tumor	214	0.048	Reference category
	Full-necrotic tumor	21	0.118	0.399	0.126	1.263
	No tumor detectable	16	0.053	0.142	0.02	1.022
Tumor morphology	No tumor detectable	16	<0.001	Reference category
	Uninodular	113	0.192	3.789	0.513	27.971
	Multinodular unilateral	57	0.073	6.251	0.840	46.513
	Multinodular bilateral	65	0.008	14.505	1.990	105.733
UICC-7	No or necrotic tumor	37	<0.001	Reference category
	UICC I	69	0.646	0.75	0.219	2.563
	UICC II	71	0.200	2.041	0.686	6.073
	UICC IIIA	25	<0.001	7.428	2.513	21.959
	UICC IIIB	32	<0.001	13.734	4.759	39.631
	UICC IIIC	7	0.001	9.808	2.627	36.611
	UICC IVA	7	<0.001	54.098	14.542	201.253
	UICC IVB	3	<0.001	180.683	34.823	937.506
hMILAN	Inside	148	Reference category
	Outside	103	<0.001	3.507	2.237	5.496
Vascular infiltration	No or necrotic tumor	37	<0.001	Reference category
	V0	148	0.254	1.829	0.648	5.161
	V1	28	<0.001	9.05	3.042	26.92
	V2	37	<0.001	14.848	5.206	42.353
	Missing data	1	0.977	0	0
Neoadj. therapy	No	107	Reference category
	Yes	144	0.071	0.676	0.441	1.035
Grading	No or necrotic tumor	37	<0.001	Reference category
	G1	35	0.272	1.937	0.596	6.299
	G2	130	0.023	3.282	1.179	9.138
	G3-4	43	<0.001	6.672	2.313	19.249
	Missing data	6	0.008	6.550	1.636	26.214

HCC = hepatocellular carcinoma.
UICC-7 = 7th edition TNM classification of Unité International Contre Cancer.
hMILAN = histologic MILAN classification.
Vascular infiltration: V0 = none, V1 = small vessels, and V2 = large vessels.
Tumor grading: G1 = low, G2 = intermediate, and G3-4 = high to anaplastic.