Liver Transplantation for Hepatocellular Carcinoma: A Single Center Resume Overlooking Four Decades of Experience
Table 7
Distribution of covariates and subcategories in HCCR versus HCCR-free postoperative episodes (cut-off time 10.4 years) () (hospital deaths and patients without HCCR within 10.4 years excluded).
Main category
Overall () (%)
Subcategory
Follow-up
<10.4 years ()
>10.4 years ()
value
Underlying disease
7 (6.1%)
Hepatitis B with D
3 (3.7%)
4 (12.1%)
0.076
35 (30.4%)
Hepatitis B
23 (28.0%)
12 (36.4%)
30 (26.1%)
Hepatitis C
20 (24.4%)
10 (30.3%)
3 (2.6%)
Hepatitis C with B
1 (1.2%)
2 (6.1%)
15 (13.0%)
Alcohol
14 (17.1%)
1 (3.0%)
16 (13.9%)
Cryptogenic
13 (15.9%)
3 (9.1%)
9 (7.8%)
Other
8 (9.8%)
1 (3.0%)
UICC-7
9 (7.8%)
No or necrotic tumor
3 (3.7%)
6 (18.2%)
0.000
19 (16.5%)
I
7 (8.5%)
12 (36.4%)
27 (23.5%)
II
16 (19.5%)
11 (33.3%)
18 (15.7%)
IIIA
18 (22.0%)
0
27 (23.5%)
IIIB
25 (30.5%)
2 (6.1%)
7 (6.1%)
IIIC
5 (6.1%)
2 (6.1%)
5 (4.3%)
IVA
5 (6.1%)
0
3 (2.6%)
IVB
3 (3.7%)
0
hMILAN
50 (43.5%)
Inside
27 (32.9%)
23 (69.7%)
0.000
65 (56.5%)
Outside
55 (67.1%)
10 (30.3%)
Before treatment
64 (55.7%)
No
43 (52.4%)
21 (63.6%)
0.274
51 (44.3%)
Yes
39 (47.6%)
12 (36.4%)
Vascular infiltration
9 (7.8%)
No or necrotic tumor
3 (3.7%)
6 (18.2%)
0.000
55 (47.8%)
0
32 (39.0%)
23 (69.7%)
19 (16.5%)
1
17 (20.7%)
2 (6.1%)
32 (27.8%)
2
30 (36.6%)
2 (6.1%)
Grading (G)
9 (8.3%)
No or necrotic tumor
3 (2.8%)
6 (5.5%)
0.000
20 (18.3%)
1
9 (8.3%)
11 (10.1%)
52 (47.7%)
2
42 (38.5%)
10 (9.2%)
28 (25.7%)
3-4
24 (22.0%)
4 (3.7%)
HCC = hepatocellular carcinoma. UICC-7 = 7th edition TNM classification of Unité International Contre Cancer. hMILAN = histologic MILAN classification. Vascular infiltration: V0 = none, V1 = small vessels, and V2 = large vessels. Tumor grading: G1 = low, G2 = intermediate, and G3-4 = high to anaplastic.
